Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 309-066-8 | CAS number: 99811-75-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
Description of key information
Three major components ranging between 5.37 and 6.56 mg/L each at ambient temperature (QSAR).
Key value for chemical safety assessment
Additional information
Valid QSAR estimations providing values for the major constituents of the test substance, within a mixture, and an GLP experimental preliminary evaluation of the water solubility of the major constituents of the test item, using a flask method according to OECD 105 / EU A6 guidelines, are available.
During the experimental study, the water solubility of the significant components obtained during the experimental preliminary study were determined as follows: peak 1: 5.52 mg/L peak 2: 11.6 mg/L.
In addition, an evaluation of the influence of the loading rate (between 0.1 and 5 g/L) has been reported. The change in loading rate led to the corresponding increase in a single peak which may correspond to a more soluble minor constituent. Otherwise, no significant change in the water solubility of the dominant test item components was observed and the ratio between the two peaks characteristic of the test item, eluting at 18.2 and 18.7 minutes, were approximately similar to the ratio observed in the standard test item.
In this study, no definitive determination of water solubility as detailed within the method guidelines was performed. The influence of initial saturation period on the final solution concentrations was not evaluated. Due to the density, close to water, and due to limitation on apparatus, difficulties on separating the pics, it was chosen to rely on QSAR results. It is for that reason that the data generated has been reported as a preliminary evaluation of water solubility and that this study was considered as supporting study only.
Finally the water solubilities of the three major constituents of the registered substance were predicted by the QSAR calculations as follows:
Constituent 1: 5.37 mg/L,
Constituent 2: 5.63 mg/L,
Constituent 3: 6.56 mg/L.
Considering that constituents 2 and 3 of the registered substance are two isomers, we assume that these two constituents elute in a single peak (peak 2) under the analytical conditions used in the experimental study. Therefore, these results are consistent with the estimated values obtained with the preliminary approach.
As no CSA is required for the tonnage band of concern, no key value was retained (neither sum, nor calculated weighted WSol, nor worst-case).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.