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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1984
Report date:
1984

Materials and methods

Test guidelineopen allclose all
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
yes
Remarks:
; purity not reported
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
Deviations:
yes
Remarks:
; purity not reported
GLP compliance:
no
Remarks:
test was performed prior to GLP-requirement

Test material

Constituent 1
Chemical structure
Reference substance name:
2,4,6-triallyloxy-1,3,5-triazine
EC Number:
202-936-7
EC Name:
2,4,6-triallyloxy-1,3,5-triazine
Cas Number:
101-37-1
Molecular formula:
C12H15N3O3
IUPAC Name:
tris(prop-2-en-1-yloxy)-1,3,5-triazine

Test animals

Species:
rabbit
Strain:
other: White Russian
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Asta-Werke AG, Bielefeld
- Age at study initiation: 4-6 months
- Weight at study initiation: 1.95-2.2 kg
- Housing: individually stainless steel cage type Asta
- Diet: ssniff, no further data
- Water: ad libitum
- Acclimation period: 1 day, in-house breeding


ENVIRONMENTAL CONDITIONS according to guideline

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
other: control patches without test substance
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL
- Concentration (if solution): undiluted, 30°C warm to reduce viscosity

Duration of treatment / exposure:
4 h
Observation period:
1 h, 24h, 48 h and 72 h
Number of animals:
3
Details on study design:
TEST SITE
- Area of exposure: dorsal between shoulder and sacral region
- % coverage: 4 patches 6.25 cm² / patch
- Type of wrap if used: Acrylastic



SCORING SYSTEM: according to guideline

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
edema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
edema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Max. score:
4
Irritation parameter:
edema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0
Max. score:
4
Other effects:
no findings

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
In this study under the given conditions the test item showed no irritant or corrosive effects. The test item does not require classification according to CLP Regulation (EC) No.1272/2008.