Registration Dossier
Registration Dossier
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EC number: 202-936-7 | CAS number: 101-37-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,4,6-triallyloxy-1,3,5-triazine
- EC Number:
- 202-936-7
- EC Name:
- 2,4,6-triallyloxy-1,3,5-triazine
- Cas Number:
- 101-37-1
- Molecular formula:
- C12H15N3O3
- IUPAC Name:
- tris(prop-2-en-1-yloxy)-1,3,5-triazine
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: White Russian
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: White Russian
- Age at study initiation: males 7-12 months, females 7-8 months
- Weight at study initiation: males: 2.48-2.67 kg, females 2.52 - 2.71 kg
- Fasting period before study: 16 h (overnight)
- Housing: individually, stainless steel cages with grating floor type ASTA, size: 48.5x40x36.5 xm supplied by ASTA Pharma AG
- Diet: Standard diet ssniff K; approx. 120 g/ day x animal
- Water: tap water, ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS: according to guideline
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: between shoulder and sacral region
- % coverage: not reported
- Type of wrap if used: occlusive bandage
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with tap water
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2000 mg/ kg bw, application was warmed up to 30 C to lower viscosity - Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: continuous observation for signs of toxicity the first 4 to 6 h p.a., then once daily; body weights were recorded at the beginning and also 7 d and 14 d p.a.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- Limit test
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occured.
- Clinical signs:
- other: 3 males showed piloerection on the first 3 days after application, no other symptoms.
- Gross pathology:
- At necropsy no findings.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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