Registration Dossier
Registration Dossier
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EC number: 202-936-7 | CAS number: 101-37-1
Specific investigations: other studies
Administrative data
- Endpoint:
- chemobiokinetics general studies
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP study with no accordance to any guideline.
Data source
Reference
- Reference Type:
- publication
- Title:
- The effect of allyl-compounds on hepatic microsomal mixed function oxidation and porphyrogenesis.
- Author:
- Ioannides, C.; Parke, D.V.
- Year:
- 1 976
- Bibliographic source:
- Chem. Biol. Interactions, 14, 241-249
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- no
- Type of method:
- in vivo
- Endpoint addressed:
- basic toxicokinetics
Test material
- Reference substance name:
- 2,4,6-triallyloxy-1,3,5-triazine
- EC Number:
- 202-936-7
- EC Name:
- 2,4,6-triallyloxy-1,3,5-triazine
- Cas Number:
- 101-37-1
- Molecular formula:
- C12H15N3O3
- IUPAC Name:
- tris(prop-2-en-1-yloxy)-1,3,5-triazine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- other: i.p. and s.c.
- Vehicle:
- propylene glycol
Results and discussion
Any other information on results incl. tables
Triallylcyanurate induced 5-ALA-synthetase activites by a factor of 2.
No significant increase in liver weight, microsomal protein, Cytochromes P-450
and b5, NADPH-cytochrome c-reductase and anilin hydroxylase. Mitochondria of tAC-treated animals showed a green colouration resulting
from haem breakdown.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
