Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Title:
Acute intraperitoneal LD50 in rat, Test n° 831156, TK 10417 (Irgafos TNPP)
Author:
Kobel
Year:
1983
Bibliographic source:
Ciba-Geigy Limited.

Materials and methods

GLP compliance:
not specified
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
other TS: Trisnonylphenyl phosphite

Test animals

Species:
rat
Strain:
other: Tif:RAIf(SPF)
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS- Age at study initiation: 7-8 weeks - Weight at study initiation: 195 to 240 g

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: distilled water containing 0.5% carboxymethylcellulose and 0.1% polysorbate 80.
Details on exposure:
Single dose of 1000 mg/kg bw, by intraperitoneal injection.
Doses:
one single dose
No. of animals per sex per dose:
10
Control animals:
other: needed for data submission
Details on study design:
- Duration of observation period following administration: Mortality and symptoms were observed daily for 14 days - Frequency of observations and weighing: 80 Animals were weighed at day 1, 7 and 14.- Necropsy of survivors performed: yes, the animals were submitted to a gross necropsy at the end of the observation period.
Statistics:
No data

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 1 000 mg/kg bw
Mortality:
No mortality occurred during the study.
Clinical signs:
Dyspnoea, exophtalmus, ruffled fur and curved body position were seen, being common symptoms in acute tests. Animals recovered within 12 days.
Body weight:
No data
Gross pathology:
At autopsy, peritoneal adhesions in the liver and spleen area were found in 8/10 animals.

Applicant's summary and conclusion

Conclusions:
LD50 (ip) >1000 mg/kg.
Executive summary:

LD50 (ip) >1000 mg/kg.