Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1979
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: U.S. EPA peer reviewed robust summary of an acute inhalation toxicity study in which basic testing parameters are in line with the current guideline.

Data source

Reference
Reference Type:
other: U.S. EPA HPV Challenge Program
Title:
Unnamed
Year:
2001
Report date:
2001

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
yes
Remarks:
6 hours exposure
GLP compliance:
no
Remarks:
study performed before GLP implementation
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-dimethoxyethane
EC Number:
203-794-9
EC Name:
1,2-dimethoxyethane
Cas Number:
110-71-4
Molecular formula:
C4H10O2
IUPAC Name:
1,2-dimethoxyethane
Details on test material:
None

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
clean air
Details on inhalation exposure:
No further data
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
6 h
Concentrations:
20 mg/L
63 mg/L
No. of animals per sex per dose:
No data
Control animals:
no
Details on study design:
No data
Statistics:
None

Results and discussion

Preliminary study:
No data
Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 20 - < 63 mg/L air
Exp. duration:
6 h
Mortality:
Please refer to "Remarks on results"
Clinical signs:
other: Please refer to "Remarks on results"
Body weight:
Please refer to "Remarks on results"
Gross pathology:
Please refer to "Remarks on results"
Other findings:
Please refer to "Remarks on results"

Any other information on results incl. tables

- 20 mg/L

Exposure to 20 mg/L for 6 hours produced only signs of irritation and slight ataxia. None of the animals died and all gained weight normally in the 14 -day observation period following exposure.

- 63 mg/L

Rats exposed to 63 mg/L showed signs of irritation at the beginning of exposure. This progressed to prostration after approximately 1.5 hours and they remained prostrate until the 6 -hour exposure was terminated. Although all of the animals survived the exposure, all of them died within 72 hours post-exposure.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Conclusions:
The median lethal concentration (LC50) of Ethylene glycol dimethyl ether after 6 hours inhalation is considered to greater than 20 mg/L.
Executive summary:

Two groups of rats were exposed to Ethylene glycol dimethyl ether vapor at concentrations of 20 and 63 mg/L.All animals from the 20 mg/L group survived the exposure and the 14 days post exposure period. All gained weight normally and no exposure related abnormalities were noted in those animals surviving 14 days. Rats exposed to 63 mg/L showed signs of irritation at the beginning of exposure. This progressed to prostration after approximately 1.5 hours and they remained prostrate until the 6 -hour exposure was terminated. Although all of the animals survived the exposure, all of them died within 72 hours post-exposure.

Based on this study the LC50 was estimated to be greater than 20 mg/L.