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Ecotoxicological information

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Acute toxicity studies have been conducted in fish, daphnia and algae. In summary, for the aquatic compartment dipropylene glycol methyl ether shows EC50s/LC50s that exceed 1000 mg/l in daphnia (48 hr), fish (96 hr) and algae (7 days). The NOEC for reproduction of Daphnia magna corresponds to the highest concentration tested of 0.5 mg/L in the long-term test, which was set very low considering the low acute toxicity of the substance on Daphnia magna. The low chronic toxicity is highlighted in a freshwater algae test with a NOEC at 1000 mg/L. An activated sludge respiration inhibition test showed an EC50 of 4168 mg/l for micro-organisms. Dipropylene glycol methyl ether is readily biodegradable and has very low potential for bioaccumulation (log Kow <1). According to REACH Annex IX requirements, long-term toxicity testing shall only be considered when the chemical safety assessment indicates the need for further investigations. Hence, long-term testing in aquatic species (fish) can be waived for dipropylene glycol methyl ether.