Registration Dossier
Registration Dossier
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EC number: 200-712-3 | CAS number: 69-72-7
Biodegradation in water and sediment: simulation tests
Administrative data
- Endpoint:
- biodegradation in water and sediment: simulation tests
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: There are no information on the test substance and no reference to any guideline in this non-GLP experiment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Degradation of different aromatic compounds by methanogenic consortia from Saale river sediment acclimated to either o-, m- or p-cresol.
- Author:
- Kaminski U., Kuschk P, Janke D
- Year:
- 1 990
- Bibliographic source:
- J. Basic Microbiol. 30 (4) : 259-265
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- Salicylic acid
- EC Number:
- 200-712-3
- EC Name:
- Salicylic acid
- Cas Number:
- 69-72-7
- Molecular formula:
- C7H6O3
- IUPAC Name:
- 2-hydroxybenzoic acid
- Details on test material:
- no data
Constituent 1
Study design
- Oxygen conditions:
- anaerobic
- Details on inoculum:
- other: methanogenic consortia acclimated to either o-, m- or p-cresol
Results and discussion
- Details on results:
- Enrichment studies indicated all 3 cresol isomers to be degradable under strict anaerobic (methanogenic) conditions, after an acclimation period of 12 to 40 days depending on the isomer. After this, the rates of substrate removal were at least twofold increased compared to fresh (non-acclimated) sediment and methane was produced according to the theory. The enzyme systems initiating methanogenic degradation of the different cresol isomers were shown to present a narrow substrate specificity.
Among the cresol-acclimated consortia, only the p-cresol-acclimated one proved able to remove salicylic acid within 24 days of incubation.
This process unexpectedly occurred without any lag and was due to decarboxylation of the test substrate to phenol. In contrast, Kuhn et al. hypothesized reductive dehydroxylation (yielding benzoic acid as the intermediate) to be the initial reaction in degradation of salicylic acid by aquifer slurries under methanogenic conditions. Interestingly, the o-cresol-acclimated consortium from Saale river sediment failed to deal with salicylic acid suggesting that this compound was not an intermediate in methanogenic degradation of o-cresol.
Applicant's summary and conclusion
- Conclusions:
- Submitter : this study indicates that salicylic acid is not readily biodegradable in anaerobic sediment. Especially we don't agree with the absence of lag in the p-cresol-acclimated consortium, as the graph shows a 4-day lag phase.
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