Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2003
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
publication
Title:
OECD SIDS 1,2-DICHLOROPROPANE
Author:
OECD SIDS
Year:
2003
Bibliographic source:
UNEP PUBLICATIONS
Report Date:
2003

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Method not available
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name: 1,2-dichloropropane

Test animals

Species:
rat
Strain:
Sherman
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Duration of exposure:
4 h
Concentrations:
Six male or female Sherman rats (approx. 100 - 150 g) were exposed to PDC vapor (nominal concentrations up to 2000 ppm) for 4 hr or 8 hr, then observed for a 14 day follow-up period.
No. of animals per sex per dose:
Sex: male/female
No. of Animals: 6

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
2 000 ppm
Exp. duration:
4 h

Any other information on results incl. tables

Results from a preliminary study, summarised in tabular form, indicate that there was 33-67% mortality following 4 hr exposure to 2000 ppm PDC (equivalent to 9.4 mg/l). There were 3/6 deaths in the definitive study following an 8 hr exposure to this same concentration. Thus the same extent of mortality was observed in rats exposed to PDC vapor for 4 hr or 8 hr. Since the longer exposure was not more hazardous than the shorter expsoure, it is concluded that these results most likely reflect the 4 hr acute toxicity of 1,2-dichloropropane in the rat.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The 4 hr inhalation LC50 for PDC in the rat is 2000 ppm (9.4 mg/l).