Registration Dossier
Registration Dossier
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EC number: 204-327-1 | CAS number: 119-47-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited but acceptable documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
- Report date:
- 1965
Materials and methods
- Principles of method if other than guideline:
- other: acute oral toxicity study
- GLP compliance:
- no
- Test type:
- other: acute oral toxicity study
Test material
- Reference substance name:
- 6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol
- EC Number:
- 204-327-1
- EC Name:
- 6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol
- Cas Number:
- 119-47-1
- Molecular formula:
- C23H32O2
- IUPAC Name:
- 2-tert-butyl-6-[(3-tert-butyl-2-hydroxy-5-methylphenyl)methyl]-4-methylphenol
- Details on test material:
- 2,2-methylene-bis-(4-methyl-6-tertiary-butyl phenol)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Albino rats
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 10000 mg/kg
- No. of animals per sex per dose:
- 10 males
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: clinical signs: depression
- Clinical signs:
- other:
Any other information on results incl. tables
Mortality: no death occurred during the study
Clinical signs: depression, noted 6 to 24 h after test substance application, recovery 24 h after application
Gross autopsy: normal
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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