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Diss Factsheets
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EC number: 680-002-1 | CAS number: 145022-44-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP and guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants)
- Qualifier:
- according to guideline
- Guideline:
- other: Commission Regulation (EU) 1152/2010
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1-ethyl-3-methyl-1H-imidazol-3-ium trifluoromethanesulfonate
- EC Number:
- 680-002-1
- Cas Number:
- 145022-44-2
- Molecular formula:
- C6 H11 N2. C F3 O3 S
- IUPAC Name:
- 1-ethyl-3-methyl-1H-imidazol-3-ium trifluoromethanesulfonate
- Details on test material:
- - Name of the test substance used in the study report: EMIM Triflat
- Test-substance No.: 09/0070-2
- Lot/batch No.: Los-Nr. 0000000001
- pH-value: ca. 5 (undiluted test substance)
- Physical state: Liquid
- Analytical purity: The test substance has been characterized by analyses
- Storage stability: The stability under storage conditions over the study period was guaranteed by the sponsor, and the sponsor holds this
responsibility
Constituent 1
Test animals / tissue source
- Species:
- other: isolated bovine cornea
- Strain:
- other: in vitro testing
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: each treatment group consisted of 3 corneas
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 750µl
Negative Control (NC)
- De-ionized water
Positive Control (PC)
- Sodium hydroxide 1% (w/v) solution in de-ionized water - Duration of treatment / exposure:
- 10 minutes
- Observation period (in vivo):
- Post-exposure incubation: 2-hours
- Details on study design:
- The objective was to assess the potential of the test substance to cause serious damage to isolated bovine corneas for product safety and regulatory purposes. The assessment of serious eye damage is included in international regulatory requirements for the testing of chemicals. Due to animal welfare reasons serious eye damage was determined using the isolated corneas from the eyes of freshly slaughtered cattle.
After application of the test material to the epithelial surface of the corneas, corneal opacity is measured quantitatively as the amount of light transmission through the cornea. Permeability is measured quantitatively as the amount of sodium fluorescein dye that passes across the full thickness of the cornea. Both measurements are used to calculate an In Vitro Irritancy Score (IVIS) of the test substance, which is used for prediction of serious eye damage.
Corneal opacity was measured quantitatively as the amount of light transmission through the cornea. Permeability was measured quantitatively as the amount of sodium fluorescein dye that passes across the full thickness of the cornea. Both measurements were used to calculate an In Vitro Irritancy Score of the test substance relative to the control corneas.
Results and discussion
Any other information on results incl. tables
The following rules of assessment apply:
IVIS | Prediction |
>55 | risk of serious damage to the eyes |
<= 55 | no risk of serious damage to the eyes |
Applicant's summary and conclusion
- Conclusions:
- Based on the observed results it was concluded, that EMIM Triflat does not cause serious eye damage in the Bovine Corneal Opacity and Permeability Test (BCOP Test) under the test conditions chosen.
- Executive summary:
The potential of EMIM Triflat to cause serious damage to the eyes was assessed by a single topical application of 750 μL of the undiluted test substance to the epithelial surface of isolated bovine corneas. Three corneas were treated with the test substance for 10 minutes followed by a 2-hours post-incubation period. Corneal opacity was measured quantitatively as the amount of light transmission through the cornea. Permeability was measured quantitatively as the amount of sodium fluorescein dye that passes across the full thickness of the cornea. Both measurements were used to calculate an In Vitro Irritancy Score of the test substance relative to the control corneas. Based on the observed results it was concluded, that EMIM Triflat does not cause serious eye damage in the Bovine Corneal Opacity and Permeability Test (BCOP Test) under the test conditions chosen.
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