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EC number: 242-901-3 | CAS number: 19234-20-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Comparable to guideline study with acceptable restrictions. No detailed clinical and ophthalmoscopic examinations were performed. Body weight determination, clinical chemistry and haematology analysis only performed in selected animals. Histopathological examination was only performed in 10 animals per sex of the control, 50 and 200 ppm group. Not all recommended standard clinical pathology parameters and organ weights were examined.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
- Reference Type:
- secondary source
- Title:
- SIDS Initial Assessment Report For SIAM 28 Paris, France, 15-17 April 2009, Chemical Name: 2-(1-methylethoxy)ethanol, CAS Number: 109-59-1
- Author:
- OECD SIDS
- Year:
- 2 009
- Bibliographic source:
- http://webnet.oecd.org/Hpv/UI/SIDS_Details.aspx?id=C1C0D516-D068-4A01-B34D-7C61F59A21D1
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 413 (Subchronic Inhalation Toxicity: 90-Day Study)
- Deviations:
- yes
- Remarks:
- no detailed clinical and ophthalmoscopic examinations; body weights, clinical chemistry and haematology parameters not determined in all animals; histopathological examination only in 10 animals per sex of the control, 50 and 200 ppm group
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 2-isopropoxyethanol
- EC Number:
- 203-685-6
- EC Name:
- 2-isopropoxyethanol
- Cas Number:
- 109-59-1
- IUPAC Name:
- 2-isopropoxyethanol
- Details on test material:
- - Name of test material (as cited in study report): isopropyl OXITOL
- Lot/batch No.: 740731
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Carworth Farms E-strain (CFE)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Tunstall Laboratory
- Age at study initiation: 12-13 weeks
- Weight at study initiation:
- Fasting period before study: animals were fasted prior to every exposure.
- Housing: animals were housed in groups of 4 per cage during acclimatisation. During the entire study, animals were kept in groups of 40 per sex and chamber.
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 3 weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17.2-19.4
- Humidity (%): not controlled
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Remarks on MMAD:
- MMAD / GSD: Not applicable.
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: 10 m³ stainless steel inhalation chamber
- Method of conditioning air:
- System of generating vapours: test atmospheres were generated by vaporising the solvent in an induced air flow to produce a concentrated vapour/air mixture which was then diluted to the desired concentration by the main air flow into the chamber. The vaporizer was a quartz-sheathed heating element wound with glass fibre tape to increase the surface area, and the solvent was fed onto this surface from a solvent reservoir by means of a micro-metering pump. The vaporiser was mounted vertically inside a 4 inch nominal bore section of industrial glass pipeline which was connected by means of a 90° bend to the inlet duct of the exposure chamber. This generation system was designed so that the vaporiser had a minimum solvent hold-up. This meant that at the end of the 6 hour exposure period when the micro-metering pump ceased solvent delivery, solvent vapours quickly cleared from the generator and the concentration of solvent in the test chamber rapidly decreased to zero.
- Temperature, humidity, pressure in air chamber: 17.2-19.4 °C
- Air flow rate: 3.5 m³/min (top dose chamber) and 4.3 m³/min (other 3 dose chambers)
TEST ATMOSPHERE
- Brief description of analytical method used: a Beckman 109A Total Hydrocarbon analyser was used for continuous monitoring of the test atmosphere during the exposure period and a Beckman GC 2A gas chromatograph fitted with a flame ionisation detector and an auto gas sampling valve was used to analyse the test atmosphere from each of the three chambers the daily exposure period.
- Samples taken from breathing zone: yes
VEHICLE
- Concentration of test material in vehicle: 25, 50, 200 ppm (v/v) - Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- Two different analysis systems were used in this experiment. One system, comprising two Beckman 109A Total Hydrocarbon analysers, enabled a continuous monitoring of the test atmospheres to be carried out during the exposure period. These analysers quickly responded to changes made in the atmosphere generation system and/or total chamber air flow rate, so that adjustments could be made to maintain the desired concentration of toxicant in the test atmospheres. This was particularly useful during the start-up period.
The other system consisted of a Beckman GC 2A gas chromatograph (GC) fitted with a flame ionization detector and an auto gas sampling valve. Test atmosphere from each of the three chambers in turn was drawn continuously through the gas sampling system, and a sample was transferred to the column every 6 min. The peak heights were averaged over the sampling period of approximately 75 min. The instrument was calibrated by means of an exponential dilution technique using a 12.5 litre stirred gas flask.
The three test atmospheres were analysed during the daily exposure period on both of the analysis systems, so that while continuous signals were obtained from the two Total Hydrocarbon analysers for two or the test atmosphere, the third atmosphere was being repeatedly chromatographed on the Beckman GC 2A. In this way, the concentrations of the solvent in the three test atmospheres could be determined, and any deviations from the desired values could be quickly spotted. The mean concentrations and ranges of solvent in the test atmospheres over the complete exposure period were 24 (16 to 30) ppm (v/v), 47 (32 to 56) ppm (v/v), and 197 (169 to 230 ) ppm (v/v). - Duration of treatment / exposure:
- 26 weeks
- Frequency of treatment:
- 6 h/day, 5 days/week
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
25, 50, 200 ppm (v/v)
Basis:
nominal conc.
- Remarks:
- Doses / Concentrations:
0.106, 0.212 and 0.850 mg/L
Basis:
other: nominal concentration based on a molecular weight of 104.15 g/mol and a molar gas volume of 24.5 L/mol
- Remarks:
- Doses / Concentrations:
106, 212 and 850 mg/m³
Basis:
nominal conc.
- Remarks:
- Doses / Concentrations:
24, 47 and 197 ppm (v/v)
Basis:
analytical conc.
- No. of animals per sex per dose:
- 40
- Control animals:
- yes, concurrent vehicle
Examinations
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: Yes
- Time schedule: animals were observed daily for general health and behaviour.
DETAILED CLINICAL OBSERVATIONS: No
BODY WEIGHT: Yes
- Time schedule for examinations: body weights were determined once weekly in 22/40 animals per sex and group at Weeks 0, 1, 2, 9, 10, 12, 18, 21, 23 and 26, respectively.
FOOD CONSUMPTION:
- Food consumption for each animal determined and mean daily diet consumption calculated as g food/kg body weight/day: No
FOOD EFFICIENCY:
- Body weight gain in kg/food consumption in kg per unit time X 100 calculated as time-weighted averages from the consumption and body weight gain data: No
WATER CONSUMPTION: No
OPHTHALMOSCOPIC EXAMINATION: No
HAEMATOLOGY: Yes
- Time schedule for collection of blood: at Weeks 0, 5, 9, 13, 18, 22 and 26
- Anaesthetic used for blood collection: No data
- Animals fasted: No data
- How many animals: 12/40 animals per sex and dose at Week 0; 1-3/40 animals per sex at Weeks 5, 9, 13, 18 and 22; 22/40 animals per sex and dose at Week 26
- Parameters checked: haemoglobin (Hb), packed cell volume (PCV), red blood cell count (RBC), white blood cell count (WBC), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), PT (prothrombin time), KCCT (kaolin cephalin coagulation time), osmotic fragilities
CLINICAL CHEMISTRY: Yes
- Time schedule for collection of blood: at Weeks 0, 5, 9, 13, 18, 22 and 26
- Animals fasted: No data
- How many animals: 12/40 animals per sex and dose at Week 0; 2-4/40 animals per sex at Weeks 5, 9, 13, 18 and 22; 20-22/40 animals per sex and dose at Week 26
- Parameters checked: protein, urea, ALP (alkaline phosphatase), SGPT (Serum glutamic pyruvic transaminase), SGOT (serum glutamic oxaloacetic transaminase), sodium (Na), potassium (K), chloride (Cl)
URINALYSIS: No
NEUROBEHAVIOURAL EXAMINATION: No - Sacrifice and pathology:
- GROSS PATHOLOGY: Yes, all animals.
HISTOPATHOLOGY: Yes, in 10 randomly selected rats per sex of the control, 50 and 200 ppm group (brain, heart, kidney, lung, spleen, liver, alimentary tract, pancreas, salivary gland, thymus, mesenteric lymph node, gonads, prostate or uterus, pituitary, adrenals, larynx, thyroid, eye and decalcified sections of nasal cavities).
Organ weights of brain, heart, liver, spleen, kidneys and testes were determined in 20-22 animals per sex and group. - Statistics:
- Body weights and organ weights were analysed by covariance analysis using initial body weight as the covariate. Reported means were adjusted for initial body weight if a significant covariance relationship existed. Where no significant covariance relationship existed, means were reported unadjusted. Covariance analysis was also used with terminal body weight as the covariance to test whether organ weight differences could be attributed to the differences in terminal body weight or if differences in organ weight were concealed by body weight variation. Reported means were adjusted for terminal body weight if a significant covariance relationship existed. This is not a true covariance analysis since terminal body weights are dependent upon treatment and has only been reported when it aids the interpretation of body and organ weight difference. Clinical chemical and haematological parameters were examined using analysis of variance. The significance of any differences between treatment and control group means was tested using the Williams t-test. However, on some occasions a monotonic dose response relationship could not be assumed, in which case Dunnett’s test was used.
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- not examined
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- 25, 50 and 200 ppm: sign. increase in 50% osmotic fragility of erythrocytes and decrease in MCH/MCHC; 50 and 200 ppm: sign. increase in 100% osmotic fragility of erythrocytes, sign. decrease in MCH and MCHC; 200 ppm: sign. decrease in RBC, Hb and PCV
- Clinical biochemistry findings:
- effects observed, treatment-related
- Description (incidence and severity):
- 25, 50 and 200 ppm: significant decrease in potassium levels
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- not examined
- Organ weight findings including organ / body weight ratios:
- effects observed, treatment-related
- Description (incidence and severity):
- 200 ppm: significant increase in relative spleen weight
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Histopathological findings: neoplastic:
- no effects observed
- Description (incidence and severity):
- 50 and 200 ppm: excessive amounts of hemosiderin in red and white pulp of spleen (m, f); 200 ppm: increase in brown pigment in Kupffer cells of liver (f), extramedullary haematopoiesis in spleen (m, f)
- Details on results:
- CLINICAL SIGNS AND MORTALITY
No treatment-related clinical signs and mortalities were observed.
BODY WEIGHT AND WEIGHT GAIN
Mean body weights were similar between all treated animals and controls.
HAEMATOLOGY
At 200 ppm, a consistent and significant reduction in haemoglobin concentration was observed in male and female rats, which was accompanied by a marginal reduction in packed cell volume (PCV) and a consistently lower erythrocyte count (RBC) during the entire study period. A consistent and significant elevated mean corpuscular volume (MCV) in the male and female rats exposed to 200 ppm was also noted. Small rises in erythrocyte counts and occurred in both male and female rats at 25 and 50 ppm, being indicative of a compensatory regeneration of erythrocytes at the lower dose levels, which however, was not sufficient to compensate the loss in erythrocytes at the highest dose level, as shown by the significant decrease in RBC and haemoglobin compared to controls. Changes in the osmotic fragility of rat erythrocytes occasionally occurred at all exposure levels, indicating a greater susceptibility of erythrocytes to haemolysis. At 25 ppm, the 50% osmotic fragility was statistically significant at Week 22 (p < 0.05) in male rats and at Week 13 (P < 0.05) and Week 18 (p < 0.01) in female rats. At the higher dose levels (50 and 200 ppm), the 50 and 100% osmotic fragility of erythrocytes was statistically significantly increased (p < 0.01) in both males and females at the end of the exposure period (26 weeks). At the same dose levels, mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) were significantly decreased compared to controls in both genders, providing further evidence for the treatment-related haemolytic effects after inhalative exposure.
In addition to the haemolytic effects, a slight reduction in kaolin cephalin coagulation time (KCCT) was observed in male and females at 200 ppm, which was not considered to be of toxicological relevance.
CLINICAL CHEMISTRY
At week 26 (study termination), plasma potassium values were significantly and dose-related decreased in both genders at all dose levels. No further significant changes in clinical parameters were observed.
ORGAN WEIGHTS
The relative weights of spleens were significantly increased in male and female rats exposed to 200 pm compared to controls. There is a correlation between increased spleen weight and the histological changes noted at the 200 ppm exposure level. In males exposed to 200 ppm, relative heart weights were significantly higher and relative liver were significantly lower compared to controls.
GROSS PATHOLOGY
No test-substance-related findings were observed at necropsy.
HISTOPATHOLOGY: NON-NEOPLASTIC
Treatment-related histopathological changes were mainly observed in liver and spleen of animals exposed to200 ppm. Considerable amounts of brown pigment were observed in Kupffer cells of the liver of female rats at 200 ppm, which could be may also be attributable to hemosiderin exposition. In males of the same dose group, small amounts of lipid in the liver parenchyma were only seen in 2/10 animals. Excessive amounts of hemosiderin were noted in the red and white pulp of the spleen in male and female rats of the 50 ppm and 200 ppm groups, respectively. Furthermore, extramedullary haematopoiesis was observed in the spleen of male and female rats exposed to 200 ppm. The accumulation of hemosiderin in spleen and possibly also in liver, as well as the extramedullary haematopoiesis in spleen are further indicative of haemolytic effects and thus correlate with the observed adverse changes in haematological parameters.
Effect levels
open allclose all
- Dose descriptor:
- LOAEC
- Effect level:
- 25 ppm (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: haematology (haemolytic effects): significant increase in the 50% osmotic fragility in erythrocytes and significant decrease in MCH and MCHC; clinical signs: significant decrease in potassium levels
- Dose descriptor:
- LOAEC
- Effect level:
- 0.106 mg/L air (nominal)
- Based on:
- test mat.
- Remarks:
- corresponding to 106 mg/m³
- Sex:
- male/female
- Basis for effect level:
- other: nominal concentration based on a molecular weight of 104.15 g/mol and a molar gas volume of 24.5 L/mol
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Table 1. Osmotic fragilities of erythrocytes in male rats
Week No. |
Atmosphere |
No. of |
Male |
||
Osmotic fragilities % NaCl producing haemolysis |
|||||
0% |
50% |
100% |
|||
0 |
0 |
3 |
0.611 |
0.403 |
0.213 |
25 |
3 |
0.611 |
0.389 |
0.233 |
|
50 |
3 |
0.622 |
0.393 |
0.200 |
|
200 |
3 |
0.590 |
0.390 |
0.200 |
|
Standard deviation of a single observation |
0.0251 |
0.0162 |
0.0115 |
||
5 |
0 |
2 |
0.720 |
0.470 |
0.230 |
25 |
3 |
0.632 |
0.455 |
0.203 |
|
50 |
3 |
0.695 |
0.466 |
0.195 |
|
200 |
3 |
0.760 |
0.515* |
0.257 |
|
Standard deviation of a single observation |
0.0425 |
0.0148 |
0.0230 |
||
9 |
0 |
3 |
0.662 |
0.382 |
0.173 |
25 |
3 |
0.732 |
0.383 |
0.135 |
|
50 |
3 |
0.730 |
0.407 |
0.179 |
|
200 |
3 |
0.722 |
0.463** |
0.175 |
|
Standard deviation of a single observation |
0.0421 |
0.0187 |
0.0309 |
||
13 |
0 |
3 |
0.660 |
0.369 |
0.117 |
25 |
3 |
0.665 |
0.427 |
0.160 |
|
50 |
3 |
0.682 |
0.427 |
0.128 |
|
200 |
3 |
0.717 |
0.473** |
0.160* |
|
Standard deviation of a single observation |
0.0307 |
0.0304 |
0.0203 |
||
18 |
0 |
2 |
0.645 |
0.350 |
0.113 |
25 |
3 |
0.673 |
0.397 |
0.118 |
|
50 |
3 |
0.657 |
0.398 |
0.130 |
|
200 |
3 |
0.713* |
0.467** |
0.114 |
|
Standard deviation of a single observation |
0.0246 |
0.0339 |
0.0198 |
||
22 |
0 |
3 |
0.660 |
0.375 |
0.193 |
25 |
3 |
0.700 |
0.433* |
0.163 |
|
50 |
3 |
0.725** |
0.428* |
0.210 |
|
200 |
3 |
0.744** |
0.480** |
0.178 |
|
Standard deviation of a single observation |
0.0254 |
0.0256 |
0.0349 |
||
26 |
0 |
22 |
0.694 |
0.398 |
0.284 |
25 |
22 |
0.708 |
0.400 |
0.274 |
|
50 |
22 |
0.726** |
0.431** |
0.306** |
|
200 |
22 |
0.754** |
0.478** |
0.317** |
|
Standard deviation of a single observation |
0.0361 |
0.0223 |
0.0218 |
Statistical significance is indicated at *p <0.05 and **p<0.01.
Table 2. Osmotic fragilities of erythrocytes in female rats
Week No. |
Atmosphere |
No. of |
Female |
||
Osmotic fragilities % NaCl producing haemolysis |
|||||
0% |
50% |
100% |
|||
0 |
0 |
3 |
0.620 |
0.441 |
0.283 |
25 |
3 |
0.623 |
0.444 |
0.210* |
|
50 |
3 |
0.662 |
0.443 |
0.210* |
|
200 |
3 |
0.655 |
0.443 |
0.230 |
|
Standard deviation of a single observation |
0.0288 |
0.0126 |
0.0329 |
||
5 |
0 |
3 |
0.608 |
0.463 |
0.248 |
25 |
3 |
0.713** |
0.490 |
0.217 |
|
50 |
3 |
0.708** |
0.505* |
0.255 |
|
200 |
3 |
0.799** |
0.550** |
0.171** |
|
Standard deviation of a single observation |
0.0231 |
0.0159 |
0.0266 |
||
9 |
0 |
3 |
0.677 |
0.433 |
0.190 |
25 |
3 |
0.697 |
0.431 |
0.158 |
|
50 |
2 |
0.760** |
0.450 |
0.180 |
|
200 |
3 |
0.767** |
0.523** |
0.190 |
|
Standard deviation of a single observation |
0.0149 |
0.0296 |
0.0353 |
||
13 |
0 |
3 |
0.653 |
0.402 |
0.145 |
25 |
3 |
0.707 |
0.428* |
0.165 |
|
50 |
3 |
0.730* |
0.437* |
0.150 |
|
200 |
3 |
0.774** |
0.507** |
0.167 |
|
Standard deviation of a single observation |
0.0303 |
0.0131 |
0.322 |
||
18 |
0 |
1 |
0.661 |
0.390 |
0.160 |
25 |
3 |
0.663 |
0.423** |
0.150 |
|
50 |
3 |
0.643 |
0.443** |
0.153 |
|
200 |
3 |
0.750* |
0.493** |
0.150 |
|
Standard deviation of a single observation |
0.735 |
0.528 |
0.188 |
||
22 |
0 |
3 |
0.662 |
0.420 |
0.157 |
25 |
3 |
0.663 |
0.407 |
0.168 |
|
50 |
3 |
0.715 |
0.448 |
0.227* |
|
200 |
3 |
0.735* |
0.528** |
0.188* |
|
Standard deviation of a single observation |
0.0339 |
0.0336 |
0.0259 |
||
26 |
0 |
3 |
0.671 |
0.396 |
0.266 |
25 |
3 |
0.723 |
0.420 |
0.266 |
|
50 |
3 |
0.722 |
0.452** |
0.307 |
|
200 |
3 |
0.747** |
0.488** |
0.289 |
|
Standard deviation of a single observation |
0.0924 |
0.0565 |
0.0515 |
Statistical significance is indicated at *p <0.05 and**p<0.01.
Applicant's summary and conclusion
- Conclusions:
- Based on the haemolytic effects observed at 25, 50 and 200 ppm (0.106, 0.212 and 0.850 mg/L), the substance is classified as STOT RE 1, H372, inhal, blood.
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