Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 200-683-7 | CAS number: 68-26-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
- Remarks:
- RCC
Test material
- Reference substance name:
- Vitamin-A-propionate
- IUPAC Name:
- Vitamin-A-propionate
- Reference substance name:
- Retinyl propionate
- EC Number:
- 230-363-2
- EC Name:
- Retinyl propionate
- Cas Number:
- 7069-42-3
- IUPAC Name:
- O~15~-propionylretinoic acid
- Details on test material:
- Vitamin A propionate (CAS No. 7069-42-3) (2.5 mio IU/g; ca. 900 mg Vitamin A propionate/g); purity was approximately 90%.
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
2 males, 1 female
- Source: Kleintierfarm Madoerin AG, Füllinsdorf (Switzerland)
- Age at study initiation: 14-15 weeks
- Weight at study initiation: 2.4-2.6 kg
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: Four days under test conditions after veterinary examination .
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 (+/- 3)
- Humidity (%): 40-70
- Air changes (per hr): 10-15
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- undiluted
- Duration of treatment / exposure:
- 4 hour(s)
- Observation period:
- The skin reaction was assessed at 1, 24, 48 and 72 hours and at 7 and 14 days intervals after removal of the application patches.
- Number of animals:
- 3
- Details on study design:
- One half millilitre of the undiluted, liquid test substance was applied (under semiocclusive conditions) onto both intact and abraded sites of the doral skin of each rabbit.
- Area of exposure: 2.5 cm x 2.5 cm
- Type of wrap if used: a surgical gauze that was covered with filter paper and then covered with a semi-occlusive dressing .
The dressing was wrapped around the abdomen and anchored with an elastic bandage .
REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 4 hours
At the end of the exposure period, the application patches and coverings were removed and the skin was flushed with water.
SCORING SYSTEM: according to OECD guideline
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal 1-3
- Time point:
- other: 24, 48, 72 hours
- Score:
- 2.1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Remarks on result:
- other: epidermal lesions, scabbing, scaling or desquamation observed in 3/3 animals
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal 1-3
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: epidermal lesions, scabbing, scaling or desquamation observed in 3/3 animals
Any other information on results incl. tables
Table 1: Individual scores and mean cumulative scores (mean of n=3) at
the intact skin (Draize scores)
animal eryth. edema mean cum symptoms
no score
-------------------------------------------------
1-hour reading
1 1 0 c
2 1 0 c
3 1 0 1.00 c
- - - - - - - - - - - - - - - - - - - - - - - - -
24-hour reading
1 2 0
2 1 0
3 2 0 1.67 c
- - - - - - - - - - - - - - - - - - - - - - - - -
48-hour reading
1 2 0
2 2 0
3 2 1 2.33 c
- - - - - - - - - - - - - - - - - - - - - - - - -
72-hour reading
1 3 0 S
2 3 0 S
3 2 2 3.33 c
- - - - - - - - - - - - - - - - - - - - - - - - -
7-day reading
1 1 0
2 1 0
3 2 0 1.33 c/EL
- - - - - - - - - - - - - - - - - - - - - - - - -
14-day reading
1 0 0
2 0 0
3 0 0 0.00
-------------------------------------------------
Mean scores 24 - 72 h reading
Animal Erythema Edema
-----------------------------
1 2.3 0.0
2 2.0 0.0
3 2.0 1.0
- - - - - - - - - - - - - - -
Mean scores 24 - 72 h reading
Animal Erythema Edema
-----------------------------
1-3 2.1 0.3
Table 2: Individual scores and mean cumulative scores (mean of n=3) at
the abraded skin (Draize scores); not relevant for assessment
animal eryth. edema mean cum symptoms
no score
-------------------------------------------------
1-hour reading
1 1 0 c
2 1 0 c
3 1 0 1.00 c
- - - - - - - - - - - - - - - - - - - - - - - -
24-hour reading
1 1 0
2 1 0
3 2 0 1.33 c
- - - - - - - - - - - - - - - - - - - - - - - - -
48-hour reading
1 2 0
2 1 0
3 2 1 2.00 c
- - - - - - - - - - - - - - - - - - - - - - - - -
72-hour reading
1 2 0 S
2 2 0 S
3 3 2 3.00 c
- - - - - - - - - - - - - - - - - - - - - - - - -
7-day reading
1 0 0
2 1 0
3 2 0 1.00 c/EL
- - - - - - - - - - - - - - - - - - - - - - - - -
14-day reading
1 0 0
2 0 0
3 0 0 0.00
-------------------------------------------------
Abrreviations used for symptoms:
c = Colouring or staining of the skin by pigment or colouring of the test substance
S = desquamation
EL = epidermal lesions, scabbing, scaling
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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