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Diss Factsheets
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EC number: 202-773-1 | CAS number: 99-62-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin sensitisation (Buehler method)
Similar to OECD guideline 406, not sensitizing in guinea pigs
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Remarks:
- in vivo study that was performed prior to current requirement for in vitro alternative testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 JUL 1985 - 20 DEC 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- yes
- Remarks:
- only 10 animals tested, not many details provided in the report
- Principles of method if other than guideline:
- only 10 animals tested, not many details provided in the report
- GLP compliance:
- not specified
- Type of study:
- Buehler test
- Justification for non-LLNA method:
- in vivo study that was performed prior to current requirement for in vitro alternative testing
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- male/female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 324 - 415g - Route:
- epicutaneous, occlusive
- Vehicle:
- not specified
- Concentration / amount:
- 100% as received
- Day(s)/duration:
- 3 weekly doses
- Route:
- epicutaneous, occlusive
- Vehicle:
- not specified
- Concentration / amount:
- 100% as received
- Day(s)/duration:
- not specified
- No. of animals per dose:
- 10
- Details on study design:
- no details given
- Positive control substance(s):
- no
- Reading:
- 1st reading
- Group:
- negative control
- Dose level:
- 0% v/v
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Remarks on result:
- other: Hours after challenge is not indicated
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- 100% v/v
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Remarks on result:
- other: Hours after challenge is not indicated . Doesn't show irritating sign
- Reading:
- 1st reading
- Group:
- positive control
- Remarks on result:
- not measured/tested
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test substance is not sensitizing in guinea pigs
- Executive summary:
A skin sensitisation test (Buehler method) was performed on guinea pigs. The test was done similar to OECD guideline 406. The sensitization potential of test item was assessed in guinea pigs using a Buehler test design. In the induction phase animals received 3 weekly applications of 100% of the test substance. Challenge was also performed with 100 % of the test substance. There were no signs of sensitization in any of the test animals. Consequently, the test substance was determined to be non-sensitizing in guinea pigs.
Reference
Preliminary tests had shown this material to be irritating to the abdomen, but not the backs of guinea pigs. During the course of the test, no irritation was observed during the induction phase using 100 % compound, so animals were challenged with the compound as received as well.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Skin sensitisation, Buehler method
A skin sensitisation test (Buehler method; Key study) was performed on guinea pigs. The test was done similar to OECD guideline 406. The sensitization potential of test item was assessed in guinea pigs using a Buehler test design. In the induction phase animals received 3 weekly applications of 100 % of the test substance. Challenge was also performed with 100 % of the test substance. There were no signs of sensitization in any of the test animals. Consequently, the test substance was determined to be non-sensitizing in guinea pigs.
Skin sensitisation, Kodak method
The skin sensitisation test (Kodak method; Supporting study) was performed on guinea pigs. The dermal application of 0.05 mL of a 1 % solution of test item in Freund's Complete Adjuvant (FCA) topically to guinea pigs produced slight to moderate erythema and slight edema for 1 -3 days. Animals were subsequently challenged by subcutaneous injection of a 10 % v/v solution of the material into the foot pad of the test guinea pigs. There was no evidence of sensitization in any of the test guinea pigs. Consequently, m-diisopropylbenzene was determined to be non-sensitizing in guinea pigs.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
respiratory sensitisation
inhalation is not considered to be a relevant route of potential human exposure
Justification for classification or non-classification
The potential for m-diisopropylbenzene to induce skin sensitization was assessed in two independent studies, which utilized either the Buehler method or a variation of the Magnusson Kligmann maximization method. In both studies, there was no evidence of skin sensitization observed, and therefore, m-DIPB does not satisfy the criteria for classification as a dermal irritant according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No 1272/2008 or UN Globally Harmonized System of Classification and Labelling of Chemicals (GHS).
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