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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12-20 November, 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- The study was conducted according to an internationally recognised method, and under GLP. The substance is adequately identified. Therefore full validation applies.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- 11 March 2011
- Type of method:
- column elution method
- Specific details on test material used for the study:
- - Physical state: white crystalline powder.
- Storage condition: Room temperature protected from direct sun light. - Key result
- Water solubility:
- 5.4 mg/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- >= 7.4 - <= 7.5
- Executive summary:
The water solubility of the test item was measured under GLP according EU A6 guideline, column elution method.
Two experiments were performed with a different flow rate, at 20.0 ± 0.5 °C.
The average of five successive samples was found as:
Test at 25 mL/h: 5.0 ± 0.3 mg/L; Test at 13 mL/h: 5.7 ± 0.2 mg/L. Individual results per flow and mean flow series results did not differ by more than 30%, so the overall mean solubility was retained.
The water solubility of the test item has been determined to be 5.4 mg/L at 20.0 ± 0.5 °C, pH 7.4-7.5.
Reference
Estimated value
QSAR determination gave 2.85 mg/L at 25 °C as the estimated value (Source: WaterNT v. 1.01, EPI Suite, EPA).
Measured value
Experiment no. 1- 25 mL/h flow rate
A 1.5 g sand portion was coated with 500 µL of the test item stock solution. A sample of 0.6148 g portion of the coated sand was introduced in the micro-column. Analytical assessments of the coated sand showed that the micro-column was thus charged with approximately 36 mg of test item.
About 0.04 mg of the test item was controlled to be voided in the rinsed volume (15 mL).
A total of five successive samples were submitted to the analysis which corresponded to the elution over a 4-hour period. The hydrosolubility was measured as mean from the five measured concentrations.
Mean concentration in water = 5.0 mg/L with a standard deviation of 0.3 mg/L.
pH of the resulting solution was measured as 7.4.
Table 1: Samples collected from the micro-column at 25 mL/h flow rate
Sample n° |
Dilution rate |
Area |
Measured mg/L(1) |
mg/L in water(2) |
1 |
1 |
624.95 |
12.60 |
5.04 |
2 |
1 |
566.81 |
11.45 |
4.58 |
3 |
1 |
653.26 |
13.17 |
5.27 |
4 |
1 |
634.23 |
12.79 |
5.12 |
5 |
1 |
632.98 |
12.76 |
5.11 |
(1) As measured in the chloroform phase resulting from a 2/5 concentration of the aqueous phase
(2) Recovery was considered as total
Experiment no. 2 - 13 mL/h flow rate
The whole procedure was reproduced without disturbing the coated sand: the micro-column was emptied and the volume of water was renewed. The system was allowed to stand for the night, and then the flow was set at 12.5 mL/h for 2 hours before the first sample was collected.
A total of five successive samples were submitted to the analysis which corresponded to the elution over a 8-hour period. All of them were used for the calculation of the hydrosolubility.
Table 2: Samples collected from the micro-column at 13 mL/h flow rate
Sample n° |
Dilution rate |
Area |
Measured mg/L(1) |
mg/L in water(2) |
1 |
1 |
700.53 |
14.11 |
5.64 |
2 |
1 |
743.00 |
14.95 |
5.98 |
3 |
1 |
580.73 |
13.71 |
5.48 |
4 |
1 |
712.27 |
14.34 |
5.74 |
5 |
1 |
705.98 |
14.21 |
5.69 |
(1) As measured in the chloroform phase resulting from a 2/5 concentration of the aqueous phase
(2) Recovery was considered as total
Mean concentration in water = 5.7 mg/L with a standard deviation of 0.2 mg/L.
pH of the resulting solution was measured as 7.5.
The second value did not differ by more than 30 % to the first one.
Mean hydrosolubility = 5.4 mg/L.
Description of key information
Slightly soluble. pH of saturated solution: 7.4 -7.5.
Key value for chemical safety assessment
- Water solubility:
- 5.4 mg/L
- at the temperature of:
- 20 °C
Additional information
A fully reliable experimental study, conducted according to a recognized EC method and under GLP, is available. It is considered as a key study, and the result is retained as key data.
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