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Diss Factsheets
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EC number: 942-639-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The physicochemical and biological data on EPICLON EXA-7250 suggest it is has a low bioavailability from the oral route, and very low by the dermal route. Most material taken in orally would probably pass through in the faeces. There is no evidence for any bioaccumulation, there is some evidence for detoxification/metabolism. It is considered likely that any absorbed substance would be detoxified and eliminated relatively quickly, with no bioaccumulation.
Please refur to the full report attached titled _15_289-412ET_EPICLON EXA-7250_Evaluation and Assessment of the Toxicokinetics.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
SUMMARY: Potential for Bioavailability and Bioaccumulation
The studies performed and the available physicochemical data are consistent with an organic molecule with a very low bioavailability and no significant indication or evidence for potential for toxicity or bioaccumulation in vivo.
The physical properties and mammalian data indicate a low bioavailability. Evidence from in vitro cytotoxicity shows reduced toxicity in the presence of S9 liver enzymes, suggesting detoxification/metabolism can occur. Also rats given >28 days of a daily dose of the maximum dose of close to 1 OOO mglkg/d, had no major toxic or reprotoxic effects; this indicates no evidence for bioaccumulation. For exposure by the oral route, there is evidence that no significant effects occur with repeated exposure; it is considered that based on limited animal studies and/or the physicochemistry of the substance, that dermal absorption would be minimal and inhalation exposure is very unlikely.
SUMMARY: Potential for Distribution and Metabolism
The large molecular weight (>500) and the very low water solubility, with a LogP of approx. 4, plus the lack of effects from maximal oral doses, would suggest that the majority of the substance would not be absorbed form an oral exposure, with most material being eliminated with the faeces. There is limited evidence that detoxification/metabolism would occur to any absorbed substance; a large molecule like this would likely be eliminated via the bile rather than the urine. The epoxide groups on the molecule would be metabolised to hydrophilic -OH groups by the Epoxide hydrolases which are present in mammalian tissues, meaning the detoxified substance would be hydrophilic and very unlikely to accumulate in fatty tissues, but would be eliminated.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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