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EC number: 630-324-3 | CAS number: 861229-15-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 1991-01 to 1992-05-06
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- 1981
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Specific details on test material used for the study:
- Purity: 99.9%
Batch No.: 4624
Emperical formula: C18H27ClO3
CAS No.: 28473-03-2 - Key result
- Conc. based on:
- test mat.
- Incubation duration:
- >= 1 - <= 3 d
- Temp.:
- 20 °C
- pH:
- >= 5 - <= 9
- Remarks on result:
- other: insoluble
- Conclusions:
- The test material was found to be insoluble (< 0.17*10-3 g/L or 0.17 ppm) in distilled water buffered to pH 5.0, 7.0 and 9.0.
- Executive summary:
The water solubility was determined according to OECD TG 105 and using the shake flask method with liquid chromatography analysis. In a preliminary test about 100 µL test substance was mixed with 100 µL distilled water and shaken. The prepared mix was examined for layers. Further aliquots of distilled water up to 10 mL were added. After 45 minutes of sonication separation of the water and test item layer was still visible. For the main test three buffered water solutions were prepared at pH 5.0, 7.0 and 9.0. A set of nine flasks per buffer were prepared. In each flask ca. 125 mg accurately weighted MCPP-P 2-EHE was added together with 25 mL buffer solution. All flasks were shaken at a thermostatically controlled water bath at 30 °C. After 24h, three flasks from each set were removed and left at ambient temperature (21.5 ± 0.5 °C) for another 24h with occasional shaking. An aliquot of the supernatant was taken and filtered through 0.45 µm filter. This procedure of removal from the water bath and acclimation at ambient temperature was repeated for the other six flasks in the set after 2 and 3 days. Using liquid chromatography, the filtered aliquots were analysed. MCPP-P 2-EHE was not detected in any of the test samples analysed, standard and quality control samples gave satisfactory results. The limit of detection of the analytical method is 0.17 µg/mL, thus, the solubility of MCPP-P 2-EHE is less than 0.17 µg/mL (0.17 ppm) in water buffered to 5.0, 7.0 and 9.0.
Reference
Preliminary solubility test:
100 µL of the test item was added to a screw-capped tube with 100 µL of distilled water. The sample was shaken, sucked up into a Pasteur pipette and examined for layers. Further aliquots of distilled water up to 10 mL total volume were added. The sample was then sonicated for 45 minutes and re-examined. Separation of the water and the test item layers was still visible.
Solubility in Aqueous Buffer Solutions:
Using the analytical method, the buffered water test samples were analysed. MCPP-P 2-EHE was not detected in any of the test samples analysed, standard and quality control samples gave satisfactory results. The limit of detection of the analytical method is 0.17 µg/mL, thus, the solubility of MCPP-P 2-EHE is less than 0.17 µg/mL (0.17 ppm) in water buffered to 5.0, 7.0 and 9.0.
MCPP-P 2-EHE has a retention time of ca. 4.8 min.
Description of key information
MCPP-P 2-EHE was found to be insoluble (< 0.17*10-3 g/L or 0.17 ppm) in distilled water buffered to pH 5.0, 7.0 and 9.0. The water solubility of the main hydrolysis product, MCPP-P acid, is 860 mg/L at 20 °C. As MCPP-P 2-EHE hydrolyses rapidly to MCPP-P acid, the water solubility of the acid will be used for further risk assessment and PNEC calculations.
Key value for chemical safety assessment
- Water solubility:
- 860 mg/L
- at the temperature of:
- 20 °C
Additional information
The test material was found to be insoluble (< 0.17*10-3 g/L or 0.17 ppm) in distilled water buffered to pH 5.0, 7.0 and 9.0.
The water solubility was determined according to OECD TG 105 and using the shake flask method with liquid chromatography analysis [MCPP-P Task Force, 1992]. In a preliminary test about 100 µL test substance was mixed with 100 µL distilled water and shaken. The prepared mix was examined for layers. Further aliquots of distilled water up to 10 mL were added. After 45 minutes of sonication separation of the water and test item layer was still visible. For the main test three buffered water solutions were prepared at pH 5.0, 7.0 and 9.0. A set of nine flasks per buffer were prepared. In each flask ca. 125 mg accurately weighted MCPP-P 2-EHE was added together with 25 mL buffer solution. All flasks were shaken at a thermostatically controlled water bath at 30 °C. After 24h, three flasks from each set were removed and left at ambient temperature (21.5 ± 0.5 °C) for another 24h with occasional shaking. An aliquot of the supernatant was taken and filtered through 0.45 µm filter. This procedure of removal from the water bath and acclimation at ambient temperature was repeated for the other six flasks in the set after 2 and 3 days. Using liquid chromatography, the filtered aliquots were analysed. MCPP-P 2-EHE was not detected in any of the test samples analysed, standard and quality control samples gave satisfactory results. The limit of detection of the analytical method is 0.17 µg/mL, thus, the solubility of MCPP-P 2-EHE is less than 0.17 µg/mL (0.17 ppm) in water buffered to 5.0, 7.0 and 9.0.
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