Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 700-242-3 | CAS number: 62037-80-3
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Although positive results were observed in one in vitro clastogenicity study with CHO cells, negative results were observed for in vitro studies in bacterial cells (Salmonella typhimurium and E. coli) and mammalian cells (mouse lymphoma cells). In vivo studies yielded negative results for chromosome aberrations (mouse bone marrow), micronucleus (mouse bone marrow), and UDS (rat liver cells). Therefore, overall, the test substance is considered negative for genotoxicity.
Short description of key information:
In Vitro (Mutagenic effects - bacterial): OECD 471; Ames study.
Negative. Reliability = 1..
In Vitro (Mutagenic effects – mammalian): OECD 476; Mouse lymphoma
study. Negative. Reliability = 1
In Vitro (Clastogenic effects - mammalian): OECD 473; Chromosome
aberrations in CHO cells. Positive. Reliability = 1
In Vivo (Clastogenic effects - mammalian): OECD 474; in vivo mouse
micronucleus study; Negative at doses up to 1300 mg/kg. Reliability = 1.
In Vivo (Clastogenic effects - mammalian): OECD 475; in vivo mouse bone
marrow chromosome aberration study; Negative at doses up to 1300 mg/kg.
Reliability = 1
In Vivo (Clastogenic effects - mammalian): OECD 486; in vivo rat UDS
study; Negative at doses up to 2000 mg/kg. Reliability = 1
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The test substance did not produce mutagenicity or clastogenicity when evaluated in laboratory animals. Based on an assessment of the robust genetic toxicity data for this substance, the substance does not need to be classified for mutagenicity according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
