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EC number: 619-290-0 | CAS number: 97780-06-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in soil
Administrative data
- Endpoint:
- biodegradation in soil: simulation testing
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 307 (Aerobic and Anaerobic Transformation in Soil)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: U.S. EPA Pesticide Assessment Guidelines Subdivision N, Series 162-1
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Society for Environmental Toxicology and Chemistry-Europe (Procedures for Assessing the Environmental Fate and Ecotoxicology in Pesticides)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- laboratory
Test material
- Reference substance name:
- Reference substance 002
- Cas Number:
- 97780-06-8
- Test material form:
- solid
- Details on test material:
- Purity: Not reported
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- Phenyl and Triazinel label
Study design
- Oxygen conditions:
- aerobic/anaerobic
- Soil classification:
- USDA (US Department of Agriculture)
- Year:
- 2 007
Soil propertiesopen allclose all
- Soil no.:
- #1
- Soil type:
- silty clay
- % Clay:
- 43
- % Silt:
- 57
- % Sand:
- 0
- % Org. C:
- 2.03
- pH:
- 7.7
- CEC:
- 16.2 meq/100 g soil d.w.
- Bulk density (g/cm³):
- 1.1
- Soil no.:
- #2
- Soil type:
- silty clay loam
- % Clay:
- 41
- % Silt:
- 59
- % Sand:
- 0
- % Org. C:
- 1.6
- pH:
- 7.7
- CEC:
- 17.1 meq/100 g soil d.w.
- Bulk density (g/cm³):
- 1.1
- Soil no.:
- #3
- Soil type:
- loam
- % Clay:
- 25
- % Silt:
- 46
- % Sand:
- 29
- % Org. C:
- 1.1
- pH:
- 7.9
- CEC:
- 1.03 meq/100 g soil d.w.
- Bulk density (g/cm³):
- 1.2
- Soil no.:
- #4
- Soil type:
- loam
- % Clay:
- 13
- % Silt:
- 38
- % Sand:
- 49
- % Org. C:
- 1.6
- pH:
- 7.5
- CEC:
- 7.7 meq/100 g soil d.w.
- Bulk density (g/cm³):
- 1.1
- Soil no.:
- #5
- Soil type:
- sandy loam
- % Clay:
- 11
- % Silt:
- 20
- % Sand:
- 69
- % Org. C:
- 1.7
- pH:
- 6.8
- CEC:
- 7.1 meq/100 g soil d.w.
- Bulk density (g/cm³):
- 1.1
Duration of test (contact time)open allclose all
- Soil No.:
- #1
- Duration:
- 120 d
- Soil No.:
- #2
- Duration:
- 120 d
- Soil No.:
- #3
- Duration:
- 120 d
- Soil No.:
- #4
- Duration:
- 120 d
- Soil No.:
- #5
- Duration:
- 120 d
Initial test substance concentration
- Initial conc.:
- 0.4 mg/kg soil d.w.
- Based on:
- act. ingr.
- Remarks:
- For all soil types
- Parameter followed for biodegradation estimation:
- radiochem. meas.
Experimental conditionsopen allclose all
- Soil No.:
- #1
- Temp.:
- 20 ± 2°C
- Microbial biomass:
- Initial: 40.6 mg C/100 g soil; at day 120: 16.9 mg C/100 g soil
- Soil No.:
- #2
- Temp.:
- 20 ± 2°C
- Microbial biomass:
- Initial: 36.2 mg C/100 g soil; at day 120: 12.1 mg C/100 g soil
- Soil No.:
- #3
- Temp.:
- 20 ± 2°C
- Microbial biomass:
- Initial: 18.7 mg C/100 g soil; at day 120: 9.4 mg C/100 g soil
- Soil No.:
- #4
- Temp.:
- 20 ± 2°C
- Microbial biomass:
- Initial: 34.9 mg C/100 g soil; at day 120: 16.2 mg C/100 g soil
- Soil No.:
- #5
- Temp.:
- 20 ± 2°C
- Microbial biomass:
- Initial: 19.3 mg C/100 g soil; at day 120: 8.0 mg C/100 g soil
Results and discussion
Material (mass) balanceopen allclose all
- Soil No.:
- #1
- % Recovery:
- 14.19
- Remarks on result:
- other: Phenyl label
- Soil No.:
- #2
- % Recovery:
- 28.26
- Remarks on result:
- other: Phenyl lablel
- Soil No.:
- #3
- % Recovery:
- 7.54
- Remarks on result:
- other: Phenyl lablel
- Soil No.:
- #4
- % Recovery:
- 9.71
- Remarks on result:
- other: Phenyl lablel
- Soil No.:
- #5
- % Recovery:
- 16.2
- Remarks on result:
- other: Phenyl lablel
- Soil No.:
- #1
- % Recovery:
- 14.81
- Remarks on result:
- other: Triazine label
- Soil No.:
- #2
- % Recovery:
- 31.57
- Remarks on result:
- other: Triazine label
- Soil No.:
- #3
- % Recovery:
- 17.66
- Remarks on result:
- other: Triazine label
- Soil No.:
- #4
- % Recovery:
- 8.71
- Remarks on result:
- other: Triazine label
- Soil No.:
- #5
- % Recovery:
- 15.08
- Remarks on result:
- other: Triazine label
Half-life / dissipation time of parent compoundopen allclose all
- Key result
- Soil No.:
- #1
- DT50:
- 29.9 d
- Type:
- other: FOMC
- Temp.:
- 20 °C
- Key result
- Soil No.:
- #2
- DT50:
- 57.4 d
- Type:
- other: DFOP
- Temp.:
- 20 °C
- Key result
- Soil No.:
- #3
- DT50:
- 29.6 d
- Type:
- other: DFOP
- Temp.:
- 20 °C
- Key result
- Soil No.:
- #4
- DT50:
- 22.6 d
- Type:
- other: DFOP
- Temp.:
- 20 °C
- Key result
- Soil No.:
- #5
- DT50:
- 26.9 d
- Type:
- other: DFOP
- Temp.:
- 20 °C
- Transformation products:
- yes
- Remarks:
- Nine transformation products that exceeded 5% of the applied radioacitivty at two sequential time points were observed in the study: IN-D5803, IN-A8768, IN-N7469, IN-N7468, IN-RXR81, IN-D5119, IN-B9161, IN-D7556, and IN-A9795.
- Evaporation of parent compound:
- no
- Volatile metabolites:
- yes
- Remarks:
- CO2
Any other information on results incl. tables
Mass balance was calculated as the percent of applied radioactivity (% AR) as presented in the table below. The extractability of DPX-A7881 decreased while the non-extractable residues (NER) increased as the study progressed. Non-extractable residues reached a peak at Day 120 for all systems ranging from 10.83-22.93%.
Volatile organics were produced in significant levels. For systems dosed with [phenyl-14C] DPX-A7881, the amount of 14CO2 evolved ranged from 25.47-51.59% AR whereas 14CO2 evolved from the triazine systems ranged from 0.96-11.92% AR. The amounts of CaCl2 and organic extractable and mineralized radioactivity in each system for Day 120 samples are summarized in the following table.
Soil |
A7881 Label |
Extractable with CaCl2 at Day 120 (%AR) |
Extractable with Organic Solvents at Day 120 |
NER at Day 120 |
Evolved 14CO2 at Day 120 |
Overall Mean Mass Balance (%AR) |
Lleida |
Phenyl |
2.7 |
14.67 |
22.7 |
51.59 |
96.89± 5.11 |
Triazine |
7.6 |
62.41 |
22.93 |
1.37 |
98.48±1.74 |
|
Tama |
Phenyl |
5.92 |
50.45 |
14.88 |
25.47 |
100.14±2.91 |
Triazine |
2.55 |
76.34 |
18.68 |
0.96 |
98.90±1.19 |
|
Gross-Umstadt (Loam) |
Phenyl |
15.82 |
20.03 |
17.99 |
46.33 |
99.61±1.69 |
Triazine |
24.51 |
55.21 |
13.28 |
8.17 |
100.52±2.40 |
|
Nambsheim(Loam) |
Phenyl |
30.17 |
27.84 |
13.37 |
34.23 |
100.99±3.42 |
Triazine |
25.07 |
47.51 |
12.79 |
11.92 |
100.01±1.87 |
|
Sassafras |
Phenyl |
8.05 |
19.47 |
19.46 |
35.42 |
93.48±7.74 |
Triazine |
21.51 |
62.32 |
10.83 |
3.05 |
99.73±0.95 |
A summary of the amount of test substance and major and minor transformation products at the termination time point and the maximum amount reached for each is presented in the following tables.
Nine transformation products that exceeded 5% of the applied radioacitivty at two sequential time points were observed in the study: IN-D5803, IN-A8768, IN-N7469, IN-N7468, IN-RXR81, IN-D5119, IN-B9161, IN-D7556, and IN-A9795.
% AR Observed on Day 120, Phenyl Label |
|||||
Component |
Lleida |
Tama |
Gross-Umstadt |
Nambsheim |
Sassafras No. 16 |
Test substance |
14.19 |
28.26 |
7.54 |
9.71 |
16.2 |
IN‑A8768 |
ND |
15.42 |
21.6 |
36.63 |
11.3 |
IN‑N7469 |
ND |
NA |
2.51 |
2.30 |
ND |
IN‑N7468 |
1.75 |
1.31 |
ND |
ND |
ND |
IN‑RXR81 |
ND |
ND |
< 5.0 |
3.01 |
< 5.0 |
IN‑D5803 |
NA |
ND |
NA |
2.89 |
ND |
IN‑D5119 |
1.44 |
ND |
2.22 |
1.48 |
ND |
ND = Not detected, NA = Not applicable, metabolite was not found in this test system. IN-RXR81 is shown as < 5.0 since it was not reported independently, but reported in the sum of “Other” metabolites that accounted for < 5 % A.R |
% AR Observed on Day 120, Triazine Label |
|||||
Component |
Lleida |
Tama |
Gross-Umstadt |
Nambsheim |
Sassafras No. 16 |
Test substance |
14.81 |
31.57 |
17.66 |
8.71 |
15.08 |
IN‑A8768 |
ND |
7.90 |
3.51 |
3.50 |
9.52 |
IN‑N7469 |
3.63 |
NA |
8.25 |
20.06 |
5.77 |
IN‑N7468 |
1.02 |
2.11 |
2.09 |
ND |
1.79 |
IN‑RXR81 |
ND |
ND |
< 5.0 |
6.14 |
< 5.0 |
IN‑B9161 |
43.81 |
11.87 |
27.59 |
18.72 |
23.35 |
IN‑D7556 |
6.74 |
21.75 |
11.68 |
9.06 |
25.90 |
IN‑A9795 |
ND |
ND |
1.36 |
4.70 |
0.00 |
ND = Not detected, NA = Not applicable, metabolite was not found in this test system. IN-RXR81 is shown as < 5.0 since it was not reported independently, but reported in the sum of “Other” metabolites that accounted for < 5 % A.R |
Maximum % AR, Phenyl Label |
|||||
Component |
Lleida |
Tama |
Gross-Umstadt |
Nambsheim |
Sassafras No. 16 |
Test substance |
93.70 (Day 0) |
89.85 (Day 0) |
95.06 (Day 0) |
97.47 (Day 0) |
95.12 (Day 0) |
IN‑A8768 |
4.99 (Day 13) |
15.42 (Day 120) |
28.48 (Day 90) |
33.63 (Day 120) |
13.84 (Day 64) |
IN‑N7469 |
1.05 (Day 64) |
ND |
2.96 (Day 41) |
6.51 (Day 64) |
1.49 (Day 41) |
IN‑N7468 |
3.57 (Day 41) |
3.67 (Day 13) |
3.8 (Day 41) |
7.04 (Day 13) |
5.14 (Day 20) |
IN‑RXR81 |
* |
* |
* |
4.83 (Day 64) |
* |
IN‑D5803 |
NA |
8.02 (Day 90) |
1.94 |
2.88 (Day 90) |
0.93 (Day 14) |
IN‑D5119 |
3.34 (Day 41) |
2.56 (20) |
2.74 (Day 13) |
5.24 (Day 90) |
5.95 (Day 41) |
ND = Not detected, NA = Not applicable, metabolite was not found in this test system, * = exact quantification of IN-RXR81 is not available for every sampling point, but in all instances the metabolite accounted for < 5 % A.R. |
Maximum % AR, Triazine Label |
|||||
Component |
Lleida |
Tama |
Gross-Umstadt |
Nambsheim |
Sassafras No. 16 |
Test substance |
92.54 (Day 0) |
94.73 (Day 0) |
94.82 (Day 0) |
98.00 (Day 0) |
94.51 (Day 0) |
IN‑A8768 |
4.95 (Day 7) |
9.86 (Day 90) |
22.77 (Day 90) |
22.46 (Day 64) |
23.17 (Day 64) |
IN‑N7469 |
4.64 (Day 90) |
ND |
8.25 (Day 120) |
20.06 (Day 120) |
5.77 (Day120) |
IN‑N7468 |
7.55 (Day 41) |
11.43 (Day 41) |
6.38 (Day 20) |
7.66 (Day 64) |
12.28 (Day 41) |
IN‑RXR81 |
* |
* |
* |
9.15 (Day 90) |
* |
IN‑B9161 |
59.01 (Day 90) |
14.37 (Day 64) |
27.59 (Day 120) |
18.72 (Day 120) |
25.61 (Day 90) |
IN‑D7556 |
7.66 (Day 90) |
21.75 (Day 120) |
11.68 (Day 120) |
9.06 (Day 120) |
25.90 (Day 120) |
IN‑A9795 |
2.28 (Day 20) |
7.04 (Day 41) |
9.04 (Day 41) |
4.7 (Day 120 |
12.13 (Day 41) |
ND = Not detected, NA = Not applicable, metabolite was not found in this test system, * = exact quantification of IN-RXR81 is not available for every sampling point, but in all instances the metabolite accounted for < 5 % A.R. |
Soil |
Model |
DT50 |
DT90 |
chi² error |
r² |
Lleida |
FOMC |
29.9 |
153.7 |
3 |
0.987 |
Tama |
DFOP |
57.4 |
320.4 |
4 |
0.975 |
Gross-Umstadt |
DFOP |
29.6 |
118.7 |
3 |
0.985 |
Nambsheim |
DFOP |
22.6 |
111.2 |
3 |
0.986 |
Sassafras |
DFOP |
26.9 |
145.8 |
5 |
0.979 |
The r² value reported in this table was calculated using the formula for model efficiency in the FOCUS (2006) guidance. |
A summary of the desorption coefficient results at zero time and Day 64 are summarized for each soil type in the following table:
Soil Name |
at Zero Time |
At (Day 64) |
Change in Kd, des From Day 0 |
||||
Kd des |
Kom des |
Koc des |
Kd des |
Kom des |
Koc des |
||
PH-Lleida |
0.52 |
14.83 |
25.57 |
7.35 |
210 |
362 |
14.2 |
PH-Tama |
2.72 |
82.29 |
142 |
48.53 |
1471 |
2535 |
17.9 |
PH-Gross-Umstadt |
0.33 |
17.22 |
29.53 |
3.32 |
175 |
302 |
10.2 |
PH-Nambsheim |
0.34 |
12.31 |
21.22 |
3.70 |
132 |
228 |
10.7 |
PH-Sassafras No. 16 |
1.12 |
38.69 |
66.70 |
6.14 |
212 |
365 |
5.5 |
TR-Lleida |
0.51 |
14.65 |
25.26 |
9.14 |
261 |
450 |
17.6 |
TR-Tama |
2.62 |
79.26 |
137 |
100 |
3044 |
5248 |
38.4 |
TR-Gross-Umstadt |
0.37 |
19.44 |
33.52 |
3.77 |
198 |
342 |
10.2 |
TR-Nambsheim |
0.36 |
12.87 |
22.18 |
2.33 |
83.36 |
144 |
6.5 |
TR-Sassafras No. 16 |
1.07 |
37.00 |
63.80 |
7.19 |
248 |
427 |
6.7 |
* (Day 64) was chosen as Kd des values generally decreased for Day 90 and 120 due to an artifact that was caused by very low concentrations of DPX A7881 in the soil. |
Applicant's summary and conclusion
- Conclusions:
- The test substance would extensively degrade to a number of metabolite products and become less prone to movement with soil water in aerobic soils.
- Executive summary:
The rate of degradation and sorption of carbon-14 labeled test substance was studied in five soils according to U.S. EPA, Pesticide Assessment Guidelines, Subdivision N, 162-1 and, OECD Guideline 307, and in compliance with the GLP standards of the United States Environmental Protection Agency. The five soils were either sandy loam, loam, or silty clay, differing significantly in their sand and clay content.
The study was conducted at 20 ± 2°C in the dark for 120 days. The moisture content of the soils was maintained between 40 and 60% MWHC (close to 75% water holding capacity at 0.33 bar). The test substance used was labeled separately in two portions, the triazine and the phenyl group. The test substance was radiolabelled at stable positions and allowed detection of all significant degradation products. The test substance was applied to each soil at a nominal rate of 0.4 µg/g soil.
Nine transformation products that exceeded 5% of the applied radioacitivty at two sequential time points were observed in the study: IN-D5803, IN-A8768, IN-N7469, IN-N7468, IN-RXR81, IN-D5119, IN-B9161, IN-D7556, and IN-A9795.
The %AR for the test substance observed on Day 120 for the phenyl label ranged from 7.54 to 28.26 and from 8.71 to 31.57 for the triazine label. There were higher %AR of IN-A8768 for the phenyl label and higher amounts of %AR of IN-N7469 for the triazine label. Low levels of %AR of IN-D5803 and IN-D5119 were found for the phenyl systems and IN-A9795 for the triazine system. For the triazine system, IN-B9161 ranged from 11.87-43.81 %AR and D7556 ranged from 6.74 to 25.90 %AR. The levels of IN-RXR81 exceeded 5%AR in more than two sampling points for the triazine label in the Nambsheim soil. The chromatograms in the study records were reviewed for occurrences of this metabolite in the other four soils as well. The review revealed that IN-RXR81 never exceeded 5%AR in the Lleida, Tama, Gross-Umstadt or Sassafras soils.
The DT50 and DT90 of the test substance were calculated using the simple first-order (SFO), first-order multi-compartment (FOMC), Hockey Stick (HS), and Double First Order Parallel (DFOP) models using Model Maker for Focus Kinetics (Focus 2006). The multi-compartment models provided best fit to the observed data across all soils. The residual values were more randomly distributed and the chi² error value was lower compared to the other models.
The desorption coefficient, Kd, des, of [14C]-test substance was calculated for each soil and label at each sampling interval using the amount of test substance extracted in CaCl2 and the soil concentration. Kom, des and Koc, des are calculated from the Walkley-Black method. The Kd des in the fourth column represents the highest Kd established throughout the study. Beyond the day in parentheses no further increase was observed. The concentration of parent test substance was so low in the soil phase that the decreasing Kd des represents an artifact. No Kd des was calculated when test substance had completely degraded.
The sorption of [14C]-test substance increased over time and subsequently its potential for mobility decreased.
Based on the results of this study, The test substance would extensively degrade to a number of metabolite products, including CO2, and become less prone to movement with soil water in aerobic soils.
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