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EC number: 407-550-4 | CAS number: 69184-17-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 9 May - 30 September 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP-Guideline study with acceptable restrictions (no information on transformation products)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 84/449/EEC, Annex V, Method C10. Adopted in 1984
- GLP compliance:
- yes
Test material
- Reference substance name:
- Methyl O-(4-amino-3,5-dichloro-6-fluoropyridin-2-yloxy)acetate
- EC Number:
- 407-550-4
- EC Name:
- Methyl O-(4-amino-3,5-dichloro-6-fluoropyridin-2-yloxy)acetate
- Cas Number:
- 69184-17-4
- Molecular formula:
- Hill formula: C8 H7 Cl2 F N2 O3 CAS formula: C8 H7 Cl2 F N2 O3
- IUPAC Name:
- methyl 2-[(4-amino-3,5-dichloro-6-fluoropyridin-2-yl)oxy]acetate
- Details on test material:
- - Name of test material (as cited in study report): Fluroxypyr methyl ester (technical)
- Substance type: technical product
- Physical state: solid, fine, black, crystalline powder
- Analytical purity: 90.8% w/w
- Lot/batch No.: C-3B
Constituent 1
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling intervals for the parent compound: minimum 6 times per group
- Sampling method:
Preliminary study: duplicate aliquots (1 mL) were removed and diluted to 10 mL with acetonitrile/0.1M orthophosphoric acid (60:40 v/v) and analysed by HPLC
Definitive study: duplicate aliquots were removed from each test solution and directly analysed by HPLC
- Sampling intervals/times for pH measurements: pH values of each test solution were measured at the beginning and at the end of the test period in both preliminary and definitive tests - Buffers:
- - pH: 4
Disodium hydrogen phosphate dodecahydrate (27.6 g) and citric acid monohydrate (12.9 g) were dissolved in distilled water (1900 mL) and the pH was adjusted to 4.0 with 1 M hydrochloric acid or 1 M sodium hydroxide. The volume was adjusted to 2000 mL with distilled water
- pH: 7
Potassium dihydrogen phosphate (6.8 g) was dissolved in distilled water (1900 mL), 1 M sodium hydroxide (30 mL) was added and the pH was adjusted to 7.0 with 1 M hydrochloric acid or 1 M sodium hydroxide. The volume was adjusted to 2000 mL with distilled water
- pH 9
Disodium tetraborate decahydrate (33.1 g) and potassium dihydrogen phosphate (3.59 g) were dissolved in distilled water (1900 mL) and the pH was adjusted to 9.0 with 1 M hydrochloric acid, or 1 M sodium hydroxide. The volume was adjusted to 2000 mL with distilled water - Details on test conditions:
- - Preliminary study: Samples (250 mL) of each buffer solution were measured into Pyrex bottles, purged with nitrogen, sealed and placed in a thermostatically controlled oven at 50 °C in the dark. Once the buffer solutions had equilibrated to the temperature of the oven they were fortified with an aliquot (100 µL) of a stock solution (4.88 mg/mL) of the test substance in acetonitrile to give a nominal test solution concentration of 1.95 mg/L. The bottles were transferred back to the oven and held in the dark until sampling was required. The oven was monitored during the period of the test to ensure that the test temperature was maintained
- Definitive study: three samples of pH4 and three samples of pH7 buffer solutions (250 mL) were measured into Pyrex bottles, purged with nitrogen, sealed and one sample placed in each of three thermostatically controlled areas (a water bath at 50 °C, a water bath at 60 °C and an oven at 70 °C) in the dark. Once the buffer solutions had equilibrated to the respective test temperatures they were fortified with aliquots (100 µL) of a stock solution (4.96 mg/mL) of the test substance in acetonitrile to give a nominal test solution concentration of 1.99 mg/L. The pH7 buffer solutions equilibrated at 60°C and 70°C were fortified with aliquots (100 µL) of a stock solution (5.11 mg/mL) of the test substance in acetonitrile to give a nominal test solution concentration of 2.05 mg/L. The bottles were transferred back to their respective storage areas and held in the dark until sampling was required. The water baths and oven were monitored during the period of the test to ensure that the test temperatures were maintained
Duration of testopen allclose all
- Duration:
- 120 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 1.91 mg/L
- Duration:
- 120 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 1.93 mg/L
- Duration:
- 120 h
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- 1.59 mg/L
- Duration:
- 497 h
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- 1.91 mg/L
- Duration:
- 261 h
- pH:
- 4
- Temp.:
- 60 °C
- Initial conc. measured:
- 1.84 mg/L
- Duration:
- 214 h
- pH:
- 4
- Temp.:
- 70 °C
- Initial conc. measured:
- 1.88 mg/L
- Duration:
- 11 h
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- 1.84 mg/L
- Duration:
- 7
- pH:
- 7
- Temp.:
- 60 °C
- Initial conc. measured:
- 1.78 mg/L
- Duration:
- 4.67 h
- pH:
- 7
- Temp.:
- 70 °C
- Initial conc. measured:
- 1.81 mg/L
- Number of replicates:
- 1 replicate per pH and temperature value
Results and discussion
- Preliminary study:
- The results from the preliminary test showed that after after 2.4 hours at pH 9 and 50 °C the test substance hydrolized by more than 50%, whereas it did not at pH 4 and 7 at the same temperature. However, at pH 4 and 7 more than 10% hydrolysis took place and therefore, additional testing at these two pH conditions was necessary
- Transformation products:
- not specified
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 4
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0 h-1
- DT50:
- 356 d
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 25 °C
- Hydrolysis rate constant:
- 0.006 h-1
- DT50:
- 4.8 d
- Type:
- (pseudo-)first order (= half-life)
Any other information on results incl. tables
Table 1. Results of the definitive hydrolysis test of Fluroxypyr methyl ester (technical)
pH |
Temperature |
Slope of log linear regression (x103) |
Kobs (x103) |
t1/2 |
4 |
50 |
-0.409 |
0.942 |
735 |
4 |
60 |
-0.665 |
1.53 |
453 |
4 |
70 |
-2.09 |
4.82 |
144 |
7 |
50 |
-19.5 |
44.9 |
15.4 |
7 |
60 |
-31.6 |
72.7 |
9.53 |
7 |
70 |
-75.5 |
174 |
3.99 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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