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EC number: 269-087-2 | CAS number: 68187-32-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from study report. Test was performed according to Flex Wash Test
- GLP compliance:
- no
- Species:
- human
- Details on test animals or test system and environmental conditions:
- 20 subjects, both males and females, aged between 18 and 65 years had to put known quantities of product on anticubital fold of the arm, massage gentle for 30 seconds and wash.
- Type of coverage:
- open
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 10% active matter
- Duration of treatment / exposure:
- 30 seconds
- Observation period:
- The test was repeated three times a day for ten consecutive days.
- Number of animals:
- 20 subjects, both males and females
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 30 seconds
- Score:
- 0.5
- Max. score:
- 1
- Reversibility:
- no data
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Skin irritation of Protelan AGL 95 was evaluated through a Flex Wash Test (10% active matter). 20 subjects, both males and females, aged between 18 and 65 years had to put known quantities of product on anticubital fold of the arm, massage gentle for 30 seconds and wash.
- Executive summary:
Skin irritation of Protelan AGL 95 was evaluated through a Flex Wash Test (10% active matter). 20 subjects, both males and females, aged between 18 and 65 years had to put known quantities of product on anticubital fold of the arm, massage gentle for 30 seconds and wash. The test was repeated three times a day for ten consecutive days. The index of average irritation according to the amended Draize classification was 0.5. Also, it has been observed that below this (0.5) value, products are not irritating. Thus, it can be concluded that the test substance is mildly irritant to skin.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other: estimated data
- Principles of method if other than guideline:
- Data is predicted by QSAR toolbox version 3.1
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Age-12 weeks
Acclimation period: at least 5 days - Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eyes of same animals
- Amount / concentration applied:
- 0.1 g
- Duration of treatment / exposure:
- single application
- Observation period (in vivo):
- 21 days
- Number of animals or in vitro replicates:
- 3
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Score:
- 17.4
- Reversibility:
- other: no effects noted
- Remarks on result:
- other: Not irritating
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The modified maximum average score (MMAS) from QSAR ,eye irritation score of l-Glutamic acid, N-coco acyl derivs., monosodium salts was estimated as 17.4.
- Executive summary:
The modified maximum average score (MMAS) from QSAR ,eye irritation score of l-Glutamic acid, N-coco acyl derivs., monosodium salts was estimated as 17.4. This score indicates that l-Glutamic acid, N-coco acyl derivs., monosodium salts is not irritating to the eye of rabbit.(as the criteria MMAS <25 is not irritating) which is also supported by the study report for the same chemical. Thus based on the weight of evidences of the study and prediction it can be concluded that the target is non irritant to eyes.
Reference
The prediction was based on dataset comprised from the following descriptors: MMAS
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
(((("a" and ("b" and ( not "c") ) ) and "d" ) and "e" ) and ("f" and "g" ) )
Domain logical expression index: "a"
Similarity boundary:Target: C(=O)(O)C(CCC(=O)O{-}.[Na]{+})NCCCCCCCCCCCC
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "b"
Referential boundary: The target chemical should be classified as Alkali Earth AND Non-Metals by Groups of elements
Domain logical expression index: "c"
Referential boundary: The target chemical should be classified as Halogens by Groups of elements
Domain logical expression index: "d"
Similarity boundary:Target: C(=O)(O)C(CCC(=O)O{-}.[Na]{+})NCCCCCCCCCCCC
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "e"
Similarity boundary:Target: C(=O)(O)C(CCC(=O)O{-}.[Na]{+})NCCCCCCCCCCCC
Threshold=80%,
Dice(Atom pairs)
Domain logical expression index: "f"
Parametric boundary:The target chemical should have a value of logP Multicase which is >= 3.86
Domain logical expression index: "g"
Parametric boundary:The target chemical should have a value of logP Multicase which is <= 5.37
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation :
It is well-known that the irritating properties of surfactants play a major role in the skin compatibility of surfactant-based formulations. As the irritation potential is dependent on the amount of the irritant interacting with the skin, a decrease in this interaction should increase the compatibility of the composition. The addition of a co-surfactant can reduce the amounts of the irritant. This has been shown by the study conducted by Sugar & Schmucker in which the addition of sodium cocoyl glutamate reduced the adsorption of SLES to the skin in a dose-dependent manner. Thus based on the weight of evidences mentioned in the end point suudies of skin irritation, it can be concluded that the target chemical is not a skin irritant but can be considered a suitable option for reducing the effect.
Eye Irritation :
The modified maximum average score (MMAS) from QSAR ,eye irritation score of l-Glutamic acid, N-coco acyl derivs., monosodium salts was estimated as 17.4. This score indicates that l-Glutamic acid, N-coco acyl derivs., monosodium salts is not irritating to the eye of rabbit.(as the criteria MMAS <25 is not irritating) which is also supported by the study report for the same chemical. Thus based on the weight of evidences of the study and prediction it can be concluded that the target is non irritant to eyes.
Justification for selection of skin irritation / corrosion endpoint:
Skin irritation of Protelan AGL 95 was evaluated through a Flex Wash Test (10% active matter). 20 subjects, both males and females, aged between 18 and 65 years had to put known quantities of product on anticubital fold of the arm, massage gentle for 30 seconds and wash. The test was repeated three times a day for ten consecutive days. The index of average irritation according to the amended Draize classification was 0.5. Also, it has been observed that below this (0.5) value, products are not irritating. Thus, it can be concluded that the test substance is mildly irritant to skin.
Justification for selection of eye irritation endpoint:
The modified maximum average score (MMAS) from QSAR ,eye irritation score of l-Glutamic acid, N-coco acyl derivs., monosodium salts was estimated as 17.4. This score indicates that l-Glutamic acid, N-coco acyl derivs., monosodium salts is not irritating to the eye of rabbit.(as the criteria MMAS <25 is not irritating) which is also supported by the study report for the same chemical. Thus based on the weight of evidences of the study and prediction it can be concluded that the target is non irritant to eyes.
Justification for classification or non-classification
Based on the weight of evidences for skin and eye irritation, it can be concluded that the target chemical is not an irritant and the substance can be considered a suitable option for reducing the irritation effect on skin.
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