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Diss Factsheets
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EC number: 266-235-8 | CAS number: 66204-44-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- fish early-life stage toxicity
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Description of key information
There is no test available on the chronic toxicity to fish using the substance. However, the available data on acute toxicity indicate that fish is the trophic level with the lowest sensitivity, as the LC50 (57.7 and 71 mg/L, Danio rerio) are much higher compared to the ErC50 (3.20 and 2.6 mg/L) of the algae (Desmodesmus subspicatus). In addition, the comparison of the acute EC50 value for Daphnia magna (28 and 37.9 mg/L) and the NOEC of the Daphnia reproduction test (1.3 mg/L) reveals that the acute-chronic ratio (ACR) is significantly lower than factor 100 (AF 10 for LC50 -> NOEC and AF 10
for acute -> chronic). Although specific negative effects of the substance (reaction product) on Daphnia reproduction have been observed, the ACR is not unexpected high. Based on these findings, it can be assumed that the substance does not cause high specific negative effects on fish reproduction.
Overall, it is unlikely that another chronic NOEC from fish would be lower. Than the NOEC available for the most sensitive taxonomic groups – algae and invertebrates. Furthermore, testing of such species would be ethically questionable and contrary to animal welfare concerns.
Therefore, a test on chronic fish toxicity is scientifically not justified.
Key value for chemical safety assessment
Additional information
In addition, in aqueous media the constituents of the substance are rapidly hydrolysed (DT50 < 1 hour). At a concentration of 0.0025% (equally to 25 mg/L) the hydrolysis equilibrium is nearly complete at the hydrolysis products formaldehyde and 2-hydroxypropylamine (HPA). Therefore, in the concentration range applied in ecotoxicity tests the reaction product is completely or nearly completely hydrolysed, and thus, observed effects are caused by the hydrolysis products.
The comparison of aquatic toxicity data for the substance and its hydrolysis products reveals clearly that the toxicity of the substance is exclusively determined by its formaldehyde content.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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