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EC number: 221-435-4 | CAS number: 3091-25-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 1998
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study followed OECD 202 and EC Guideline 92/69/EEC, but with no GLP information provided.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- not specified
- Principles of method if other than guideline:
- Method: other: OECD 202 (1) and EC Guideline 92/69/EEC (2).
- GLP compliance:
- not specified
Test material
- Reference substance name:
- mono-n-octyltin trichloride
- IUPAC Name:
- mono-n-octyltin trichloride
- Reference substance name:
- ZK 26384
- IUPAC Name:
- ZK 26384
- Details on test material:
- - Name of test material (as cited in study report): mono-n-octyltin trichloride
- Analytical purity: 98.86%
- Lot/batch No.: Be 98/44
- Vapour pressure: 0.06 hPa at 25 degrees C
- Safety precautions: routine
- Expiry date/stability: until at least May 1999
- Storage conditions: dry, dark, refrigeration (4 - 6 degrees C)
- Water solubility: 0.33 mg/L at 20 degrees C
- Other: the tin carbon bond of the octyltin compounds is stable in aquous solutions.
- Molecular formula: C8H17Cl3Sn
- Molecular weight: 338.291
Constituent 1
Constituent 2
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
No information.
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- No information.
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- 100 mg of mono-n-octyltin trichloride was dissolved in 1000 mL tap water under constant stirring for 24 hours. Thereafter, the solution was filtered through a glassfibre filter. The filtered solution was used as a test solution. Characteristics of test solution:
- Conductivity: 731 µS/cm
- Hardness (CaCO3): 263 mg/L
- Ca:Mg ratio: 4.4:1
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Parent animals were kept in glass vessels in water of the same quality and temperature as under experimental conditions. The animals were continuously fed with a laboratry culture of microalgae, e.g, Chlorella vulgaris. The Daphnia were exposed for 48 hours under static conditions and were not fed during the test period. The light/dark rhythm was adjusted to 12 hours/12 hours. The Daphnia were between 0 and 24 hours old.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- Immobilisation and visual abnormalities were recorded at 24 and 48 hours.
Test conditions
- Hardness:
- 263 mg/L
- Test temperature:
- 20.8-21.6 degrees C. Changes in the temperaure were below the required margin of ± 1 degree C.
- pH:
- The pH varied between 7.8 at the beginning and 8.5 at the end of the test and was in the rage of 6 - 9 required y the pertinent water quality SOP.
- Dissolved oxygen:
- The range of dissolved oxygent was between 7.7 and 8.8 mg/L. the oxygen content was above the 60 % saturation limit demanded in the SOP.
- Salinity:
- No information.
- Nominal and measured concentrations:
- Nominal concentration was <1 mg/L.
- Details on test conditions:
- - No. of organisms per vessel: 5
- No. of vessels per concentration (replicates):4
- No. of vessels per control (replicates):4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: tap water
- Ca/mg ratio: 263 mg/L
- Conductivity: 731 µS/cm
- Intervals of water quality measurement:0 and 48 hours
OTHER TEST CONDITIONS
- Photoperiod: 12 hours light/12 hours dark - Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.33 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- The hydrographical parameters determined during the exposure were all in the required range. Therefore the quality criteria of th etest were fulfilled. The saturated solution of mono-n-octytin trichloride with the concentration of <1 mg/L (calculated on the basis of TOC analysis) had no adverse effects on the mobility of Daphnia. Thus, it can be concluded that the EC50/48 hours to Daphnia magna is higher than a saturated solution.
- Results with reference substance (positive control):
- No information.
- Reported statistics and error estimates:
- No information.
Any other information on results incl. tables
The hydrographical parameters determined during the exposure were all in the required range. Therefore, the quality criteria of the test were fulfilled. The saturated solution of mono-n-octyltin trichloride had no adverse effects on the mobility of Daphnia (Water solubility of the test substance under the test condition was 0.33 mg/L.) The 48 -hr EC50 to Daphnia magna was higher than the concentration of saturated solution.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- No immobilized Daphnia was observed in the test solution. The 48-hr EC50 of Mono-n-octyltin trichloride to Daphnia magna was greater than 0.33 mg/L.
- Executive summary:
Short-term toxicity of of mono-n-octyltin trichloride to Daphnia magna was determined in a static aquatic system following OECD 202 and EC Guideline 92/69/EEC. 20 juvenile Daphnia magna were used for the test solution of mono-n-octyltin trichloride and 20 for the tap water control. The Daphnia were exposed for a period of 48 hours under static conditions. Immobilization was recorded at 24 and 48 hours. The test temperature was in the range of 20.8 to 21.6 ºC, the pH ranged between 7.8 and 8.5, and the oxygen concentration between 7.7 and 8.8 mg/L. The light/dark rhythm was adjusted to12 hours/12 hours. No immobilised Daphnia magna was observed in the test solution at saturation. It was determined that the 48 -hr EC50 was greater than the water solubility of the test substance, which is 0.33 mg/L under the test conditions.
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