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Diss Factsheets
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EC number: 220-863-9 | CAS number: 2921-57-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Negative results were obtained in an invitro assay for gene mutation in Salmonella typhimurium TA98, TA100, TA1535, TA1538 with concentrations of methylprednisolone sulfonate in the range 250 to 2000 ug/plate. An invitro assay for gene mutation at the hprt locus in Chinese hamster ovary cells and concentrations in the range 2000 to 10,000 ug/ml of methylprednisolone sulfonate. Both these studies were carried out in the absence and presence of metabolic activation.
There was no increase in unscheduled DNA synthesis in primary rat hepatocytes with concentrations in the range 5 to 1000 ug/ml methylprednisolone suleptanate.
Methylprednisolone was not mutagenic in a DNA cell binding assay.
Short description of key information:
Read-across data on methylprednisolone.
Source: European Medicines Agency (EMEA), The European Agency for the Evaluation of Medicinal Products, Veterinary Medicines Evaluation Unit, Committee for Veterinary Medicinal Products; Methylprednisolone, Summary Report (2001).
Available from, as of November 20, 2007: http://www.emea.europa.eu/pdfs/vet/mrls/079801en.pdf **PEER REVIEWED**
Endpoint Conclusion:
Justification for classification or non-classification
On the basis of the negative results in the mutagenicity tests performed on the substance methylprednisolone, no classification is needed for methylprednisolone succinate.
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