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EC number: 213-551-9 | CAS number: 976-56-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The test substance was not irritating to rabbit skin and minimally irritating to the rabbit eye.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1967
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: young adult animals
- Weight at study initiation: about 3 kg
- Housing: single housing
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: at least 7 days - Type of coverage:
- occlusive
- Preparation of test site:
- other: one test site on each animal shaved, the other test site shaved and abraded
- Vehicle:
- water
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 g
- Concentration: 0.5 g test substance moistened with 0.5 mL of water
VEHICLE
- Amount applied: 0.5 mL water - Duration of treatment / exposure:
- 24 h
- Observation period:
- 72 h
- Number of animals:
- 4 (2 males and 2 females)
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 cm * 2.5 cm each of the two application sites
- Type of wrap if used: Gauze patches containing test material were secured by thin strips of adhesive tape, the entire trunk was wrapped with impervious plastic sheeting securely taped in place.
SCORING SYSTEM: according to Draize - Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 h / 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 h / 72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- No dermal reactions at any timepoint.
- Interpretation of results:
- GHS criteria not met
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1967
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- other: Federal Hazardous Substances Labeling Act (1964)
- Deviations:
- no
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 100 mg - Duration of treatment / exposure:
- directly after application, the eyelids were held together for a second and eyes were not washed out afterwards
- Observation period (in vivo):
- 72 h
- Number of animals or in vitro replicates:
- 6 (3 males, 3 females)
- Details on study design:
- SCORING SYSTEM:
according to "Illustrated Guide for Grading Eye Irritation by Hazardous Substances", issued by the Superintendent of Documents, Govemment Printing Office, Washington, D.C. - Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24 h /48 h / 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24 h /48 h / 72 h
- Score:
- 0.05
- Max. score:
- 2
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24 h /48 h / 72 h
- Score:
- < 0.16
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24 h /48 h / 72 h
- Score:
- < 0.11
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 h
- Irritant / corrosive response data:
- After 24 hours, minimal redness and chemosis were observed in three and two animals, respectively. In addition, one animal showed minimal reaction of the iris with a score of 1 after 24 hours. All findings cleared after 48 hours.
- Interpretation of results:
- GHS criteria not met
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
To assess the skin irritation potential of the test substance, a study was conducted using 4 young adult rabbits (2 males and 2 females). 24 hours before dermal application, the backs of the rabbits were shaved free of hair with electric clippers, the shaved area constituting about 10 % of the total body surface-area. On each rabbit two test sites, located at the mid-line of the back about 10 centimeters apart, were used. Immediately before application the left-hand site was abraded by making epidermal abrasions, the right-hand site remained intact. Application to each site was in the form of 2.5 cm square gauze patches containing 0.5 g of test material moistened with 0.5 mL of water. These were secured by thin strips of adhesive tape, and the entire trunk wrapped with impervious plastic sheeting securely taped in place. After 24 hours the binders and patches were removed and the sites separately assessed for both erythema and edema on a graded scale of 0 to 4. 72 hours after application a second similar assessment was made. Scores for individual intact and abraided sites were recorded separately for erythema formation and for edema formation at each of the two time intervals. As a result, reactions were neither observed after 24 h nor after 72 hours (mean score erythema formation: 0, mean score edema formation: 0). The test substance therefore did not cause skin irritation under the test conditions chosen.
Eye irritation
An acute eye irritation study was carried out and interpreted in accordance with the Federal Hazardous Substances Labeling Act and published on September 17th, 1964. Six albino rabbits were used (3 males and 3 females), care being taken to protect them from extraneous materials (e.g. sawdust) that might enter the eye. All rabbits were free from observable eye defects. The test material was placed in one eye of each animal by gently pulling the lower lid away from the eyeball to form a cup into which the test substance was dropped. The lids were then gently held together for a second and the animal released. The eyes were examined, and the grade of ocular reaction recorded at 24, 48 and 72 hours. The grades of response were recorded in accordance with those depicted in the "Illustrated Guide for Grading Eye Irritation by Hazardous Substances", issued by the Superintendent of Documents, Government Printing Office, Washington, D.C.. The following mean scores were calculated: cornea score: 0, iris: 0.05, conjunctivae: 0.16, chemosis 0.11. On the basis of these values the test substance is considered to be non-irritating to the rabbits’ eyes.
Justification for classification or non-classification
Classification, Labelling, and Packaging Regulation (EC) No 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008 (CLP). As a result the substance is not considered to be classified for skin or eye irritation under Regulation (EC) No 1272/2008.
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