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Diss Factsheets
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EC number: 213-361-6 | CAS number: 939-48-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Isopropyl benzoate is not acutely toxic to rats by the oral, dermal or inhalation routes of exposure.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 2000
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline method according to GLP, documentation is incomplete.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Remarks:
- Principles of GLP, UK GLP methods
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Route of administration:
- oral: drinking water
- Vehicle:
- water
- Remarks:
- DI water
- Details on oral exposure:
- VEHICLE: Water
MAXIMUM DOSE VOLUME APPLIED: 2000 mg/Kg - Doses:
- Single dose 2000 mg/KG
- No. of animals per sex per dose:
- Five male and five female rats
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Every day for 14 days
- Other examinations performed: clinical signs, body weight and any other signs of toxicity observed and recorded. AT the end of the study the animals were killed and macroscopically examined post mortem. - Preliminary study:
- There were no deaths and no significant signs of toxicity. Acute oral median dose is in excess of 2000 mg /Kg
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No
- Clinical signs:
- other: No clinical toxicity signs were observed
- Other findings:
- - Other observations: No deaths, toxicity or significant findings at post mortem.
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Acute oral LD50 dose of IPB is in excess of 2000 mg /kg.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- adequate
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Experimental studies were performed in a reliable research institute prior to establishment of international guidelines and GLP
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Precedes establishment of guideline and GLP. It is assumed that this scientific study was performed according to the accepted standards of its day
- GLP compliance:
- no
- Remarks:
- Precedes establishment of GLP
- Test type:
- standard acute method
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- saturated vapour
- Details on study design:
- Minimal data is available on this 1951 study. The maximum concentration was described qualitatively as "saturated vapour" and the amount of time elapsed before death was observed in any animal was reported. The type of exposure is most likely whole body, but is not specifically described. After exposure, animals were observed and mortality assessed for 14 days.
- Sex:
- not specified
- Dose descriptor:
- LC0
- Effect level:
- other: described qualitatively as "saturated vapour"
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: No deaths occurred in rats after 4 h of inhalation exposure to saturated vapour
- Conclusions:
- No deaths occurred in rats after 4 h of inhalation exposure to saturated vapour of isopropyl benzoate
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- adequate
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2000
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study according to GLP, however, documentation is incomplete.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- single 24 hour dermal application.
- Doses:
- 2000mg/kg of lsopropyl Benzoate
- No. of animals per sex per dose:
- Five male and five female rats
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Daily
- Other examinations performed: clinical signs, body weight: yes - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No
- Clinical signs:
- other: Signs of slight skin irritation had fully regressed by day 14, with the exception of one animal, which had scabs at the edge of treatment site at day 15. There was no significant finding at postmortum observation.
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal median lethal dose was estimated to be in excess of 2000 mg/Kg to male and female rats.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- adequate
Additional information
The LD50 values in rats for isopropyl benzoate by the oral and dermal routes of administration are greater than 2000 mg/kg bw. The saturated vapour of isopropyl benzoate resulted in no lethality in exposed rats.
Justification for selection of acute toxicity – oral endpoint
experimental data
Justification for selection of acute toxicity – inhalation endpoint
experimental data; qualitative
Justification for selection of acute toxicity – dermal endpoint
experimental data
Justification for classification or non-classification
The LD50 values in rats for isopropyl benzoate by the oral and dermal routes of administration are greater than 2000 mg/kg bw and so do not meet the criteria for classification for acute toxicity in Regulation EC No. 1272/2008. The substance is not considered acutely toxic to rats by the inhalation route.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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