Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 208-436-5 | CAS number: 528-50-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 13 - ongoing
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- April 13, 2004
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- LOT No.: L1021174
Appearance: white, dry powder
Expiry date: 28 October 2023
Storage condition: at room temperature, protected from light
Safety precautions: according to MSDS
Purity: 99.54 % - Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 100 mg/L
- Vehicle:
- yes
- Remarks:
- dilution water (ISO Medium)
- Details on test solutions:
- The test solution used in the test was prepared by mechanical dispersion without using of any solubilising agent, as the substance is well water soluble.
The test solution was prepared by dissolving an amount of 0.0304 g test item in 304 mL dilution water (ISO Medium) to obtain a nominal concentration of 100 mg/L. After the formulation procedure the test animals were immediately introduced into test solution. Untreated control ran in parallel. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Strain/clone: Daphnia magna (Straus)
- Age at study initiation (mean and range, SD): less than 24h
- Method of breeding: -
- Source: TOXI-COOP ZRT
- Feeding during test: NO
ACCLIMATION
- Acclimation period: Test animals were bred under similar (or the same) conditions as that used during the exposure period (holding water, temperature, background colour etc.), therefore additional acclimatisation before the test was not necessary. Brood daphnids were maintained in dilution water at the test temperature for at least 48 hours prior to the start of the test.
- Type and amount of food: algal suspension of Raphidocelis subcapitata
: - Test type:
- static
- Water media type:
- freshwater
- Remarks:
- Reconstituted water (ISO Medium, according to OECD 202)
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- approximate theoretical total hardness of 249 mg/L (as CaCO3), calculated based on the concentration of calcium and magnesium ions in ISO medium
- Test temperature:
- 19.8 – 20.0°C
- pH:
- 7.24 – 7.65
- Dissolved oxygen:
- of 8.44 – 8.78 mg/L
- Nominal and measured concentrations:
- nominal: 100 mg/L
measured: 88.6 – 113.0 mg/L (i.e. within ± 20% of the nominal) - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Details on results:
- - Behavioural abnormalities: no
- Other biological observations: no
- Mortality of control: no
- Other adverse effects control: no
- Immobilisation of control: no
- Abnormal responses: no
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: no
- Effect concentrations exceeding solubility of substance in test medium: no - Results with reference substance (positive control):
- - Results with reference substance valid? YES
- Relevant effect levels: immobilization
- Limit test: no
- ECx: 24h EC50: 1.06 mg/L (95 % confidence limits: 1.02 – 1.10 mg/L) - Validity criteria fulfilled:
- yes
- Conclusions:
- In a GLP-compliant study according to OECD TG 202 with Daphnia magna, cellobiose did not induce any effects at the limit concentration of 100 mg/L.
- Executive summary:
The purpose of this study was to evaluate the influence of the test item on the mobility respectively survival of Daphnia magna.
Young Daphnia were exposed to the test item in aqueous test media for 48 hours under defined conditions. The number of Daphnia no longer capable of swimming at the end of the test or being dead was recorded.
In a preliminary test, the test item revealed no toxic effect on daphnids up to a concentration of 100 mg/L (limit concentration). Therefore, a limit test was performed using only this concentration level and a control in order to demonstrate that the test item is not toxic to Daphnia magna up to at least the concentration of 100 mg/L, in line with the OECD 202 guideline.
The test was run according to international test guidelines using the recommended test species Daphnia magna.
Reference
Description of key information
In a GLP-compliant study according to OECD TG 202 with Daphnia magna, cellobiose did not induce any effects at the limit concentration of 100 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- > 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.