Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 207-837-2 | CAS number: 497-18-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation/corrosion: The test item produced a primary irritation index of 0.3 and was classified as a mild irritant to rabbit skin according to the Draize classification scheme. No corrosive effects were noted.
Eye irritation: The test substance was instilled into one eye of each of nine albino rabbits (6 not rinsed and 3 rinsed). No signs of systemic toxicity or mortality were observed and the primary irritation index of 0.33 classifies the test substance as non-irritating. Irrigation with water increased the score to 2.0 at 1 hour and the classification to practically non-irritating.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin Irritation/Corrosion:
Introduction.
The study was performed to assess the irritancy potential of the test item to the skin of the New Zealand White rabbit. The method was designed to be compatible with the following:
- OECD Guidelines for the Testing of Chemicals No. 404 "Acute Dermal Irritation/Corrosion" (adopted 24 April 2002)
- Method B4 Acute Toxicity (Skin Irritation) of Commission Regulation (EC) No. 440/2008
Results.
3-minute and 1-hour semi-occluded applications of the test item to the intact skin of one rabbit produced no evidence of skin irritation.
A single 4-hour, semi-occluded application of the test item to the intact skin of three rabbits produced very slight erythema and very slight oedema. Two treated skin sites appeared normal at the 24-hour observation and the remaining treated skin site appeared normal at the 48-Hour observation. No corrosive effects were noted.
Conclusion.
The test item produced a primary irritation index of 0.3 and was classified as a mild irritant to rabbit skin according to the Draize classification scheme.
The test item did not meet the criteria for classification according to the Classification, Labelling and Packaging Regulation or the Globally Harmonised Classification System.
Eye Irritation
The objective of the study was to determine the irritative potential of the test material following a single dose to the eye of albino rabbits.
The study utilized one dose level (0.1 ml) administered to the right eye of each rabbit, the left eye served as the untreated control. A total of nine rabbits were used (6 not rinsed and 3 rinsed).
When the test substance was instilled into one eye of each of nine albino rabbits (6 not rinsed and 3 rinsed). No signs of systemic toxicity or mortality were observed and the primary irritation index of 0.33 classifies the test substance as non-irritating. Irrigation with water increased the score to 2.0 at 1 hour and the classification to practically non-irritating.
Based on the results the substance does not meet the criteria for classification according to CLP.
Justification for selection of skin irritation / corrosion endpoint:
The study has been conducted according to OECD Guideline 404 and GLP and is adequately reported. The study has been assigned a reliability 1.
Justification for selection of eye irritation endpoint:
The study has been conducted according to standard guidelines and GLP and is adequately reported. The study has been assigned a reliability 1.
Justification for classification or non-classification
The results from skin irritation and eye irritation studies were evaluated according to the Classification, Labelling and Packaging Regulation (CLP).
Skin irritation:
The test item produced a maximum individual mean score of 0.33 for erythema and oedema (based on scores at 24, 48 and 72) in one animal only and all effects resolved by 48 hours. The substance therefore does not meet the criteria for classification according to the Classification, Labelling and Packaging Regulation (CLP), which requires a mean score for erythema and oedema of ≥2.3 - ≤4.0 in at least 2 of 3 animals or inflammation to persist for 14 days in at least 2 animals.
Eye irritation:
The results of the study were also evaluated separately according to the Classification, Labelling and Packaging (CLP) Regulation, based on the mean scores of individual animals for corneal opacity, iritis, conjunctival redness and chemosis (based on scores at 24, 48 and 72 hours). The scores were all below the threshold values for a 'positive respones'. All effects were fully reversible. The substance therefore does not meet the criteria for classification according to the Classification, Labelling and Packaging (CLP) Regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.