Registration Dossier

Administrative data

Description of key information

In a well conducted acute oral toxicity study (Safepharm Laboratories, 1982) conducted using a protocol comparable to the now deleted OECD 401, and to GLP, the LD50 for the sodium salt of DTPMP was >10 ml/kg bw in rats (reviewer comment: presumed equivalent to >5838 mg active salt/kg).
Taking the results of this study together with an additional study conducted at SafePharm Laboratories (1982b), an oral LD50 of 10 ml/kg < LD50 < 15 ml/kg is determined for the test substance in the rat (reviewer comment: presumed equivalent to 5838 mg < LD50 < 8757 mg
active salt/kg bw).
In an acute dermal toxicity study (Safepharm Laboratories, 1982) conducted using a protocol comparable to OECD 402, and to GLP, the LD50 for the sodium salt of DTPMP was >10 ml/kg bw (>5838 mg active salt/kg bw, equivalent to >4602 mg parent acid) in rats.
There are no data for the inhalation route.

Key value for chemical safety assessment

Additional information

The most reliable studies were selected as the key studies. Available supporting studies also showed sodium salts of DTPMP to be of low acute toxicity.

Justification for classification or non-classification

The available data do not suggest that sodium salts of DTPMP should be classified for acute toxicity by any route.