Registration Dossier
Registration Dossier
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EC number: 231-679-3 | CAS number: 7681-82-5
Endpoint summary
Administrative data
Description of key information
Additional information
The acute toxicity to daphnia of iodide was determined (INERIS Parc Technologique ALATA, 2012) according to OECD test guideline 202 following GLP procedure to give a result of 48hrs-EC50 as 1.27 mg/L (95%CL, 1.19 -1.38 mg/L). There is another data on daphnia acute toxiciy (Laboratoire d'Ecotoxicologie Parc technologique ALATA, 1996) of KI according to method of “French standard”, which was similar to OECD test guideline 202, which is 48 hrs- EC50 as 7.5 mg/l. As the study for NaI gives lower tolerance value for daphnia and the test itself is more reliable (Klimisch score 1), the 48 hrs- EC50 of 1.27 mg/l is taken as the key value.
One study of acute toxicity of iodide to algae was published in well known journal “water research” (Bringmann, G., and R. Kuhn, 1980). It was not a standard test and without declaration of GLP compliance, and in the test the 7 days cell multiplication inhibition test was applied to the model organism, Scenedesmus quadricauda (green algae) for iodide, but fulfilled basically scientific principles. The results showed the toxicity threshold (≥3% inhibition of the biomass of green algae) of iodide to green algae is 2370 mg/l.
On the other hand, testing for long term aquatic toxicity is not considered to be necessary as the CSR does not indicate a risk to aquatic organisms when considering the environmental risk mitigation measures. Furthermore, iodine is a natural ubiquitously present essential trace element. It is highly mobile and cycles through all environmental compartments via a range of mechanisms including disproportionation to different oxidation states by abiotic and biotic mechanisms coupled with binding to organic matrices and biological organisms. These act to significantly mediate the aquatic toxicity when compared to laboratory conditions. There is no long-term toxicity test to daphnia, but existing data are adequate to hazard classification and chemical safety assessment.
Based on above information the most sensitive species can be determined to be daphnia, and the 48 hrs - EC50 (1.27 mg/l) is taken as key vale in the hazard classification and chemical safety assessment.
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