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Diss Factsheets
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EC number: 200-896-5 | CAS number: 75-73-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- other: OECD QSAR Toolbox
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- Used males only, number tested at each concentration was 6.
- Deviations:
- no
- GLP compliance:
- not specified
- Test type:
- other: standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Trifluoromethane
- EC Number:
- 200-872-4
- EC Name:
- Trifluoromethane
- Cas Number:
- 75-46-7
- Molecular formula:
- CHF3
- IUPAC Name:
- Trifluoromethane
Constituent 1
- Specific details on test material used for the study:
- - Purity: 99.936%
Test animals
- Species:
- rat
- Strain:
- other: ChR-CD®
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 8 weeks
- Weight at study initiation: 238 - 285 g
- Fasting period before study: not reported
- Housing: rats were housed in suspended stainless-steel, wire mesh cages
- Diet : Purina Certified Rodent Chow® #5O02 ad libitum)
- Water: ad libitum
- Acclimation period: not reported
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Chamber temperature never exceeded 27°C during any exposure.
- Humidity (%): not reported
- Air changes (per hr): not reported
- Photoperiod (hrs dark / hrs light): not reported
Administration / exposure
- Route of administration:
- inhalation: gas
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: 20 L glass exposure chamber
- Exposure chamber volume: 20 L
- Method of holding animals in test chamber: not reported
- Source and rate of air: 10 L/min.
- Method of conditioning air: not reported
- System of generating test atmosphere: Atmospheres of the test material were generated by metering the test gas through a single stage regulator and a Brooks R6-15A flowmeter. The gas passed through Teflon® lines into a mixing flask (500 mL , 3-neck, round bottom). Metered dilution air and oxygen were added at the mixing flask. The stream entered the 20 L glass exposure chamber directly through the top. Total flow was 10 L/min.
TEST ATMOSPHERE
- Brief description of analytical method used: Gas standards and samples were analyzed using a Wilks Scientific Miran I infrared analyzer at a wavelength of 8.75 microns. Standards were prepared daily by quantitative dilutions of the gas in calibrated gas bottles. Gas samples were taken at 15-minute intervals using a Tekmar gas tight syringe. Chamber concentrations were determined by comparison with a standard curve. A mean and standard deviation were calculated for each exposure. Chamber temperature and oxygen were also monitored throughout each exposure.
- Samples taken from breathing zone: not reported
VEHICLE
- Composition of vehicle (if applicable): air
Chamber temperature never exceeded 27°C during any exposure. - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- Mean Measured concentrations: 18900, 186000 and 663000 ppm
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: observed daily (excluding weekends)
- Frequency of weighing: weighed daily (excluding weekends)
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs and body weight
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 663 000 ppm
- Mortality:
- No mortality at any concentration
- Clinical signs:
- other: 18900 ppm - Exposure: no signs; Post-Exposure: None 186000 ppm - Exposure: Reduced response to sound; Post-Exposure: None 633000 ppm - Exposure: No response to sound, gasping, labored breathing, sluggishness and compulsive gnawing on basket (1 a
- Body weight:
- 18900 ppm - Slight weight loss 24-48 hrs post-exposure
633000 ppm - Slight weight loss 24 hours post-exposure - Gross pathology:
- not examined
Applicant's summary and conclusion
- Interpretation of results:
- other: ALC is greater than 663000 ppm
- Conclusions:
- ALC > 663000 ppm
This study and the conclusions which are drawn from it fulfill the quality criteria (validity, reliability, repeatability). - Executive summary:
Groups of 8 week old ChR-CD® male albino rats were exposed to the test substance gas in air for single 4-hr periods. The ALC of the test substance gas is greater than 663000 ppm, the maximum concentration generated. Clinical signs observed during exposure included reduced response to sound, gasping, labored breathing, sluggishness, and compulsive gnawing on basket. Mild weight loss was observed 24-48 hrs post exposure but normal weight gain was achieved thereafter.
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