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EC number: 906-078-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study meets the EC Standards (conducted equivalent to OECD 401). Non GLP. Deviations: no details on test material, limited details on test animals and environmental conditions. However, dose, number of animals and observation period and considering mortality observed, the result is considered reliable with restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Remarks:
- study pre-dates introduction of GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Geranyl formate
- EC Number:
- 203-339-4
- EC Name:
- Geranyl formate
- Cas Number:
- 105-86-2
- Molecular formula:
- C11H18O2
- IUPAC Name:
- (E)-3,7-dimethylocta-2,6-dien-1-yl formate
- Reference substance name:
- Citronellyl formate
- EC Number:
- 203-338-9
- EC Name:
- Citronellyl formate
- Cas Number:
- 105-85-1
- Molecular formula:
- C11H20O2
- IUPAC Name:
- 3,7-dimethyloct-6-en-1-yl formate
- Reference substance name:
- Geraniol
- EC Number:
- 203-377-1
- EC Name:
- Geraniol
- Cas Number:
- 106-24-1
- Molecular formula:
- C10H18O
- IUPAC Name:
- (E)-3,7-dimethylocta-2,6-dien-1-ol
- Reference substance name:
- Rhodinyl formate
- EC Number:
- 205-456-6
- EC Name:
- Rhodinyl formate
- Cas Number:
- 141-09-3
- Molecular formula:
- C11H20O2
- IUPAC Name:
- 3,7-dimethyloct-7-en-1-yl formate
- Test material form:
- liquid
Constituent 1
Constituent 2
impurity 1
impurity 2
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): CFI-70 Geranyl Formate
- Description: Colourless liquid
- Received: January 22, 1971
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 150 to 250 g
- Fasting period before study: overnight
- Housing: Individually housed
- Diet: Free access to commercial diets
- Water: Free access to water
- Acclimation period: No data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 50%
MAXIMUM DOSE VOLUME APPLIED: 6 mL/kg - Doses:
- 6000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: Toxic signs and mortality were recorded at one and four hours and then once daily
- Necropsy of survivors performed: A necropsy was performed on all animals which died during the study and on those killed by cervical dislocation at termination.
Results and discussion
- Preliminary study:
- The results obtained from the range-finding study showed that no deaths occurred in rats which received CFI-70 at any dose level up to 10 mL/kg.
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 6 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- One animal died.
- Clinical signs:
- Piloerection and ataxia was observed in one animal.
- Body weight:
- No data.
- Gross pathology:
- The stomach of the animal that died 24 hours following administration of the test substance was filled with fluid. No tissue damage was seen in any animal killed at the termination of the study.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute oral toxicity study with rats, performed equivalent to OECD 401 guidelines, an LD50 of >6000 mg/kg bw was determined.
- Executive summary:
The test substance CFI-70 Geranyl Formate was tested in an acute oral toxicity study with rats, performed equivalent to OECD 401 guideline. One animal died. Piloerection and ataxia was observed in one animal. The stomach of the animal that died 24 hours following administration of the test substance was filled with fluid. No tissue damage was seen in any animal killed at the termination of the study.
Based on the results, an LD50 of >6000 mg/kg bw was determined.
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