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Diss Factsheets
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EC number: 201-186-8 | CAS number: 79-21-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-2 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Peracetic acid
- EC Number:
- 201-186-8
- EC Name:
- Peracetic acid
- Cas Number:
- 79-21-0
- Molecular formula:
- C2H4O3
- IUPAC Name:
- Peracetic acid generated by perhydrolysis of N-acetylcaprolactam by hydrogen peroxide in alkaline conditions
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Source: Harlan CPB Zeist, The Netherlands
- Strain: Hsd/Cpb:WU Wistar
- Age: Not indicated
- Weight: 169-194 g (males), 145-172 g (females)
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- - Application volume: 2 mL/kg bw (2000 mg/kg bw)
- Area covered: aliquots of the test material were taken and applied over a strip gauze of about 40 cm^2 - Doses:
- 2000 mg/kg of product (= 17.8 mg/kg of peracetic acid)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of post-exposure period: 14 days
- Removal of test substance: yes, after 24 hours the gauze patches were peeled off
- Examinations: Clinical signs and mortality (0.5, 1, 2, 3, 4 and 6 hours after dosing and then twice daily), local irritation on days 1, 3, 7 and 14, body weights (days 0, 7 and 14), gross necropsy at study termination.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: based on product (0.89% PAA), only dose tested; no mortalities
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 17.8 mg/kg bw
- Remarks on result:
- other: based on PAA (0.89% in product)
- Mortality:
- No mortalities.
- Clinical signs:
- other: Signs of mild irritation in most animals (white and/or red spots on treated skin, complete recovery after 12 days)
- Gross pathology:
- One female showed a maculate thymus. This was not considered to be a treatment related effect. No other findings.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 after dermal application of the test material is greater than 2000 mg/kg bw (corresponding to greater than 17.8 mg/kg bw peracetic acid). No classification with respect to acute dermal toxicity is required.
- Executive summary:
In a study to assess the acute dermal toxicity of PAA a single dermal dose of 2000 mg/kg bw was applied under an occlusive dressing to the shaved intact skin of groups of five male and five female Wistar rats. The animals were weighed one day before dosing, at the day of dosing and at 2, 7 and 14 days after treatment. Any sign of intoxication occurring during the 14-day observation period was recorded. Gross post-mortem examination was done in all rats at the end of the 14-day observation period.
None of the rats died within the 14-day observation period. White and/or red spots were noted on the treated skin after removal of the bandage. These spots got brown and encrusted during the observation period. The skin symptoms subsided after 12 days. No other clinical signs were observed. Transient weight loss was observed in both sexes in the first few days of the study. Thereafter body weight gain appeared to be normal. This transient weight loss was considered to be partly a consequence of stress induced by the bandaging procedure (the study design) and partly consequence of stress induced by the irritating properties of the test material. At autopsy, no treatment related abnormalities were recorded for any of the animals.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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