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EC number: 481-150-8 | CAS number: 500011-86-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water and sediment: simulation tests
Administrative data
- Endpoint:
- biodegradation in water: sewage treatment simulation testing
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 01/28/2006 - 11/11/2006
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented, GLP and conducted in accordance with OECD Guideline 301B.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 301B
- Deviations:
- no
- Remarks:
- The study was conducted according to the guideline in effect at time of study conduct.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- DBC80
- IUPAC Name:
- DBC80
- Reference substance name:
- -
- EC Number:
- 481-150-8
- EC Name:
- -
- Cas Number:
- 500011-86-9
- Molecular formula:
- C9H5BrClN3O2
- IUPAC Name:
- 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid
- Reference substance name:
- 1H-Pyrazole-5-Carboxylic Acid, 3-Bromo-1-(3-Chloro-2-Pyridinyl)-
- IUPAC Name:
- 1H-Pyrazole-5-Carboxylic Acid, 3-Bromo-1-(3-Chloro-2-Pyridinyl)-
- Details on test material:
- - Name of test material (as cited in study report): IN-DBC80
- Physical state: Tan powder
- Analytical purity: 96.7%
- Lot/batch No.: 008
- Expiration date of the lot/batch: July 22, 2008
- Storage condition of test material: Stored in the dark at room temperature.
Constituent 1
Constituent 2
Constituent 3
- Radiolabelling:
- no
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- - Source of inoculum/activated sludge: Local sewage treatment works.
- Preparation of inoculum for exposure: 4 hour aeration in laboratory.
- Pretreatment: Solids level of homogeneous sample determined by dry weight analysis.
- Initial cell/biomass concentration:Test vessels inoculated with 30 mg/L total suspended solids of inoculum. - Duration of test (contact time):
- 29 d
Initial test substance concentrationopen allclose all
- Initial conc.:
- 10 other: mg C/L
- Based on:
- test mat.
- Initial conc.:
- 5 other: mg C/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Volume of test solution/treatment: 3 L
- Composition of medium: Standard mineral salts test media solution.
- Additional substrate: No
- Test temperature: 20-23 degrees Celcius
- pH: 6.8-7.2
- pH adjusted: no
- Aeration of dilution water: 70-90 ml per minute, filtered through a carbon trap to remove CO2.
- Suspended solids concentration: 30 mg/L
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: 5 L amber-glass culture bottles, stoppered, with constant airflow by outlets connected to 3 Dreschel bottles containing 100 mL of 0.0125 M barium hydroxide each.
- Number of culture flasks/concentration: 2
- Measuring equipment: CO2 measured via titration of the barium hydroxide solutions in the Dreschel bottles.
- Test performed in closed vessels due to significant volatility of test substance: No. Closed vessels due to estimation parameter being measured.
- Details of trap for CO2 and volatile organics if used: 3 Dreschel bottles connected in series to outlets from test vessels, each containing 100 mL 0.0125 M barium hydroxide.
SAMPLING
- Sampling frequency: Day 0, 2, 4, 6, 8, 10, 12, 16, 22, 28, and 29.
- Sampling method: 20 mL barium hydroxide solution drawn from collection bottle.
CONTROL AND BLANK SYSTEM
- Inoculum blank: Mineral salts medium plus inoculum.
-Reference control- Sodium benzoate, mineral salts medium, and inoculum.
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
- Test performance:
- Cummulative CO2 production in the control vessels after 29 days was 103 mg. This falls within the acceptable range for this method, and confirms that the inoculum was viable and the test was valid.
% Degradationopen allclose all
- % Degr.:
- 41
- Parameter:
- CO2 evolution
- Sampling time:
- 29 d
- Remarks on result:
- other: 10 mg C/L
- % Degr.:
- 16
- Parameter:
- CO2 evolution
- Sampling time:
- 6 d
- Remarks on result:
- other: 5 mg/L
- % Degr.:
- 68
- Parameter:
- CO2 evolution
- Sampling time:
- 16 d
- Remarks on result:
- other: 5 C/L
- % Degr.:
- 82
- Parameter:
- CO2 evolution
- Sampling time:
- 29 d
- Remarks on result:
- other: 5 mg C/L
- Transformation products:
- no
- Evaporation of parent compound:
- not measured
- Volatile metabolites:
- not measured
- Residues:
- not measured
- Results with reference substance:
- Sodium benzoate had degraded 99% in 29 days, confirming the validity of the test.
Any other information on results incl. tables
-Results for IN-DBC80 at a concentration of 10 mg C/L indicate that it is not readily biodegradable.
-Additional testing with a concentration of 5 mg C/L indicate that it is biodegradable.
Applicant's summary and conclusion
- Conclusions:
- Under the tested conditions, a 5 mg C/L solution of IN-DBC80 degraded 16%, 68%, and 82% in 6, 16, and 29 daysrespectivley. A 10 mg C/L solution degraded 41% in 29 days. INDBC80 would not be considered readily biodegradable by the requirements of the guideline based on the test at 10 mg C/L, however the results of the test at 5 mg C/L show that IN-DBC is biodegradable.
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