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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: restriction: early study report; short study description. Otherwise scientifically reliable

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1966

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: according to BASF-internal standard
Principles of method if other than guideline:
Method: other: Estimation of the approximative LD50 value according to BASF-internal standard
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Test substance: as prescribed by 1.1 - 1.4

Test animals

Species:
rat
Strain:
other: US rats
Sex:
male/female
Details on test animals and environmental conditions:
no data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
Observation period: 14 days
Test substance given as 2, 20 and 30% aqueous solution
Doses:
200, 1600, 3200, 4000, 5000, 6400 ccm/kg
No. of animals per sex per dose:
10
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
5 170 mg/kg bw
Based on:
test mat.
Mortality:
see table below
Clinical signs:
Staggering, abdominal and lateral position, narcosis; female rats: sometimes bloody urine
Gross pathology:
sometimes bloody urine, several kidney damage

Any other information on results incl. tables

Dose (cmm/kg) 

 Conc. (%)

 No. of animals

 Dead animals within            

 

 

 

 1 hour

 24 hours

 48 hours

 7 days

 14 days

 6400

 30

 10

 5/10

 9/10

 9/10

 9/10

 9/10

 5000

 30

 10

 0/10

 5/10

 5/10

 5/10

 5/10

 

 30

 10

 1/10

 3/10

 3/10

 3/10

 3/10

 4000

 30

 10

 0/10

 1/10

 1/10

 1/10

 1/10

 

 30

 10

 2/10

 4/10

 5/10

 5/10

 5/10

 3200

 30

 10

 1/10

 1/10

 2/10

 2/10

 2/10

 1600

 20

 10

 0/10

 0/10

 0/10

 0/10

 0/10

 200

 2

 10

 0/10

 0/10

 0/10

 0/10

 0/10

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
In a reliable acute oral toxicity study where original data is available, male and female rats were subjected to doses of up to 6400ml/kg of 2-(2-(2-butoxyethoxy)ethoxy)ethanol and subsequently observed for a period of 14 days. An LD50 value of ~5170mg/kg was obtained.
Executive summary:

In a reliable acute oral toxicity study where original data is available, male and female rats were subjected to doses of up to 6400ml/kg of 2-(2-(2-butoxyethoxy)ethoxy)ethanol and subsequently observed for a period of 14 days. An LD50 value of ~5170mg/kg was obtained.