Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

Short description of key information on bioaccumulation potential result: 
No bioaccumulation potential based on study results from supporting substance (structural analogue or surrogate) as 2-butoxyethanol.
Short description of key information on absorption rate:
An in vitro study determined that the permeability of 2-(2-(2-butoxyethoxy)ethoxy)ethanol to human skin is quite low. The permeability co-efficient was determined to be 22 +/-8.6ug/cm2/hr, which is around 1% of the skin penetration rate of the shorter chain glycol ether ethylene glycol methyl ether. Exposure to the substance also caused no significant deterioration of skin barrier properties.

Key value for chemical safety assessment

Bioaccumulation potential:
no bioaccumulation potential
Absorption rate - dermal (%):
1

Additional information

Absorption, Distribution & Excretion:

Skin Absorption
Human abdominal whole skin (2.54 cm sq) was mounted in a glass diffusion apparatus (at 30 +/- 1 degree C) and the diffusion of triethylene glycol monobutyl ether was monitored during a 12-hr period using gas chromatography (n=6). The integrity of the epidermal membranes was first assessed by measuring permeability of membranes to tritiated water. Epidermal membranes displaying permeability constants greater than 1.5 x 10E-3 cm/hr were deemed to have been damaged during preparation and were rejected. The mean steady state of absorption for triethylene glycol monobutyl ether was 22.2 ug/cm sq/hr (SD +/- 8.59), which was 100-fold less than that of ethylene glycol monomethyl ether. Test material did not increase permeability of the membrane (damage ratio of 1.26).

Metabolism

No metabolism data were located for the category members but the read-across data from supporting substance (structural analogue or surrogate) as 2-butoxyethanol indicate no bioaccumulation potential based on study results.

Discussion on absorption rate:

An in vitro study determined that the permeability of 2-(2-(2-butoxyethoxy)ethoxy)ethanol to human skin is quite low. The permeability co-efficient was determined to be 22 +/-8.6ug/cm2/hr, which is around 1% of the skin penetration rate of the shorter chain glycol ether ethylene glycol methyl ether. Exposure to the substance also caused no significant deterioration of skin barrier properties.