Registration Dossier
Registration Dossier
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EC number: 205-592-6 | CAS number: 143-22-6
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
- Type of study / information:
- absorption
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Human abdominal whole skin (2.54 cmE2) was mounted in a glass diffusion apparatus (at 30 +/- 1 degree C) and the diffusion of triethylene glycol monobutyl ether was monitored during a 12-hr period using gas chromatography (n=6).
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-(2-(2-butoxyethoxy)ethoxy)ethanol
- EC Number:
- 205-592-6
- EC Name:
- 2-(2-(2-butoxyethoxy)ethoxy)ethanol
- Cas Number:
- 143-22-6
- Molecular formula:
- C10H22O4
- IUPAC Name:
- 2-[2-(2-butoxyethoxy)ethoxy]ethanol
- Reference substance name:
- triethylene glycol monobutyl ether
- IUPAC Name:
- triethylene glycol monobutyl ether
- Details on test material:
- Purity of test material (POLYSOLV-TB, triethylene glycol monobutyl ether) was 96.91%.
Constituent 1
Constituent 2
Results and discussion
Any other information on results incl. tables
The mean steady state of absorption for triethylene glycol monobutyl ether was 22.2 micrograms/cm2/hr (SD +/- 8.59), which was 100-fold less than that of ethylene glycol monomethyl ether. Test material did not increase permeability of the membrane (damage ratio of 1.26).
Applicant's summary and conclusion
- Conclusions:
- The mean steady state of absorption for triethylene glycol monobutyl ether was 22.2 micrograms/cm2/hr (SD +/- 8.59), which was 100-fold less than that of ethylene glycol monomethyl ether. Test material did not increase permeability of the membrane (damage ratio of 1.26).
Treatment did not alter epidermal permeability. - Executive summary:
The mean steady state of absorption for triethylene glycol monobutyl ether was 22.2 micrograms/cm2/hr (SD +/- 8.59), which was 100-fold less than that of ethylene glycol monomethyl ether. Test material did not increase permeability of the membrane (damage ratio of 1.26). Treatment did not alter epidermal permeability.
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