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Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1986

Materials and methods

Type of study / information:
absorption
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Human abdominal whole skin (2.54 cmE2) was mounted in a glass diffusion apparatus (at 30 +/- 1 degree C) and the diffusion of triethylene glycol monobutyl ether was monitored during a 12-hr period using gas chromatography (n=6).
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
Purity of test material (POLYSOLV-TB, triethylene glycol monobutyl ether) was 96.91%.

Results and discussion

Any other information on results incl. tables

The mean steady state of absorption for triethylene glycol monobutyl ether was 22.2 micrograms/cm2/hr (SD +/- 8.59), which was 100-fold less than that of ethylene glycol monomethyl ether. Test material did not increase permeability of the membrane (damage ratio of 1.26).

Applicant's summary and conclusion

Conclusions:
The mean steady state of absorption for triethylene glycol monobutyl ether was 22.2 micrograms/cm2/hr (SD +/- 8.59), which was 100-fold less than that of ethylene glycol monomethyl ether. Test material did not increase permeability of the membrane (damage ratio of 1.26).
Treatment did not alter epidermal permeability.
Executive summary:

The mean steady state of absorption for triethylene glycol monobutyl ether was 22.2 micrograms/cm2/hr (SD +/- 8.59), which was 100-fold less than that of ethylene glycol monomethyl ether. Test material did not increase permeability of the membrane (damage ratio of 1.26). Treatment did not alter epidermal permeability.