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Toxicity to other aquatic organisms

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Expert Judgement 

Due to the absence of chemical groups or other structural alerts this substance is not considered to exhibit an high hazard potential.
Triethylene glycol butyl ether or 2-(2-(2-butoxyethoxy)ethoxy)ethanol as member of “The High Boiling Ethylene Glycol Ethers category“ is of low priority for further work based on a low hazard potential.
The results suggest for 2-(2-(2-butoxyethoxy) ethoxy) ethanol that direct and indirect exposure of other aquatic organisms is unlikely.
Therefore testing for Toxicity to other aquatic organisms does not need to be performed.

Additional information

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 10(SRC), determined from a structure estimation method(2), indicates that triethylene glycol monobutyl ether is not expected to adsorb to suspended solids and sediment(SRC).

Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 9.5X10-14 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 3(SRC), from an estimated log Kow of 0.02(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC).

The theoretical BODs for triethylene glycol monobutyl ether are 0, 5 and 24% for 5, 10 and 20 days, respectively(8), triethylene glycol monobutyl ether is expected to biodegrade slowly in water(SRC).

These results suggest for 2-(2-(2-butoxyethoxy) ethoxy) ethanol that direct and indirect exposure of other aquatic organisms is unlikely.


(1) Swann RL et al; Res Rev 85: 17-28 (1983)

(2) Meylan WM et al; Environ Sci Technol 26: 1560-67 (1992)

(3) Lyman WJ et al; Handbook of Chemical Property Estimation Methods. Washington, DC: Amer Chem Soc pp. 4-9, 15-1 to 15-29 (1990)

(4) Meylan WM, Howard PH; Environ Toxicol Chem 10: 1283-93 (1991)

(5) Franke C et al; Chemosphere 29: 1501-14 (1994)

(6) Meylan WM, Howard PH; J Pharm Sci 84: 83-92 (1995)

(7) Meylan WM et al; Environ Toxicol Chem 18: 664-72 (1999)

(8) Dow Chemical Company; The Glycol Ethers Handbook. Midland, MI: Dow Chemical Co. 97 pp (1990)]