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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

HQEE is not irritating to skin and slightly irritating to the eye.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Qualifier:
no guideline followed
Principles of method if other than guideline:
O.5 g of substance was applied to the skin of 5 guinea pigs for 24 hours under an occlusive dressing.
GLP compliance:
no
Remarks:
However was subject to Quality Assurance
Species:
guinea pig
Strain:
other: Cr1:(HA) BR Hartley
Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Remarks:
Moistened with water
Amount / concentration applied:
0.5 g
Duration of treatment / exposure:
24 hours
Observation period:
15 days
Number of animals:
5 Females
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 24/48 hours
Score:
0
Max. score:
0
Reversibility:
other: Not applicable
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 15 days
Score:
0
Max. score:
0
Reversibility:
other: Not applicable
Irritant / corrosive response data:
No signs of irritation were observed over the 15 day observation period
Interpretation of results:
other: CLP criteria (Reg 1272/2008) are not met
Conclusions:
HQEE was not irritating to guinea pig skin.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
no
Remarks:
However was subject to Quality Assurance
Species:
rabbit
Strain:
New Zealand White
Vehicle:
unchanged (no vehicle)
Amount / concentration applied:
100mg
Duration of treatment / exposure:
Not applicable
Observation period (in vivo):
7 days
Number of animals or in vitro replicates:
6 animals (3 washed and 3 unwashed)
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 24/48/72 hours
Score:
0
Max. score:
0
Reversibility:
other: Not applicable
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 24/48/72 hours
Score:
0
Max. score:
0
Reversibility:
other: Not applicable
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 24/48/72 hours
Reversibility:
fully reversible within: 7 days
Remarks on result:
other: The study report only reports the conjunctival effects as "slight". Thus it is not possible to provide the actual scores.
Irritant / corrosive response data:
In unwashed eyes signs of slight irritation consisted of moderate erythema (3/3) and slight oedema (1/3) of the nictitating membranes. All effects were fully reversible by Day 7.

The report does not provide quantitative eye scoring data.

Interpretation of results:
other: CLP criteria (Reg 1272/2008) are not met
Conclusions:
HQEE was slightly irritating to rabbit eye
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

HQEE is not irritating to skin and slightly irritating to the eye in reliable in vivo studies.

Justification for selection of skin irritation / corrosion endpoint: Only one study available. The study is Klimisch 2.

Justification for selection of eye irritation endpoint: Only one study available. The study is Klimisch 2.

Justification for classification or non-classification

HQEE does not cause skin irritation and the degree of eye irritancy is insufficient to meet the classification criteria. Hence HQEE is not classified for skin or eye irritancy.