Registration Dossier
Registration Dossier
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EC number: 202-213-6 | CAS number: 93-04-9
Endpoint summary
Administrative data
Description of key information
Adsorption / desorption
The adsorption coefficient Koc in soil and in sewage sludge of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 121 for testing of Chemicals (Experimental study report, 2019). The solutions of the test substance and reference substances were prepared in appropriate solvents. A test chemical solution was prepared by dissolving 4 mg of test chemical in acetonitrile to prepare 400 mg/L and filtered through 0.22 nm nylon syringe filter. pH of the resulting solution was 5.7. Each of the reference substance and test substance were analysed by HPLC at 210 nm. After equilibration of the HPLC system, Urea was injected first, the reference substances were injected in duplicate, followed by the test chemical solution in duplicate. Reference substances were injected again after test sample, no change in retention time of reference substances was observed. Retention time tR were measured, averaged and the decimal logarithms of the capacity factors k were calculated. The graph was plotted between log Koc versus log k.The linear regression parameter of the relationship log Koc vs log k were also calculated from the data obtained with calibration samples and therewith, log Koc of the test substance was determined from its measured capacity factor. The reference substances were chosen according to estimated Koc range of the test substance and generalize calibration graph was prepared. Both were analyzed on HPLC considering the similar conditions. After analyzing on above conditions calibration curve of selected reference substances was prepared to obtain log Koc value. The reference substances were Formamide, 2-Nitrobenzamide, p-Toluamide , Aniline, 2 - Nitrophenol , Benzamide and Phenanthrene having Koc value ranging from 1.3 to 3.7. The Log Koc value of test chemical was determined to be 3.280±0.001 dimensionless at 25°C.This log Koc value indicates that the substance has a moderate sorption to soil and sediment and therefore have slow migration potential to ground water.
Additional information
Adsorption / desorption
The adsorption coefficient Koc in soil and in sewage sludge of test chemical was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 121 for testing of Chemicals (Experimental study report, 2019). The solutions of the test substance and reference substances were prepared in appropriate solvents. A test chemical solution was prepared by dissolving 4 mg of test chemical in acetonitrile to prepare 400 mg/L and filtered through 0.22 nm nylon syringe filter. pH of the resulting solution was 5.7. Each of the reference substance and test substance were analysed by HPLC at 210 nm. After equilibration of the HPLC system, Urea was injected first, the reference substances were injected in duplicate, followed by the test chemical solution in duplicate. Reference substances were injected again after test sample, no change in retention time of reference substances was observed. Retention time tR were measured, averaged and the decimal logarithms of the capacity factors k were calculated. The graph was plotted between log Koc versus log k.The linear regression parameter of the relationship log Koc vs log k were also calculated from the data obtained with calibration samples and therewith, log Koc of the test substance was determined from its measured capacity factor. The reference substances were chosen according to estimated Koc range of the test substance and generalize calibration graph was prepared. Both were analyzed on HPLC considering the similar conditions. After analyzing on above conditions calibration curve of selected reference substances was prepared to obtain log Koc value. The reference substances were Formamide, 2-Nitrobenzamide, p-Toluamide , Aniline, 2 - Nitrophenol , Benzamide and Phenanthrene having Koc value ranging from 1.3 to 3.7. The Log Koc value of test chemical was determined to be 3.280±0.001 dimensionless at 25°C.This log Koc value indicates that the substance has a moderate sorption to soil and sediment and therefore have slow migration potential to ground water.
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