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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
other: expert statement
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: An extended assessment of the toxicokinetic behaviour of butylethanolamine was performed, taking into account the chemical structure, the available physico-chemical data and the available toxicity data.

Data source

Referenceopen allclose all

Reference Type:
other: Expert statement
Title:
Unnamed
Year:
2013
Report date:
2013
Reference Type:
other: prediction by the OECD QSAR Toolbox
Title:
Unnamed
Year:
2013
Report date:
2013

Materials and methods

Objective of study:
absorption
distribution
excretion
metabolism
Test guideline
Qualifier:
according to guideline
Guideline:
other: expert statement according to the TGD, Part I, Annex IV, 2003); ECHA Guidance R7c., 2008
Deviations:
no
Principles of method if other than guideline:
An assessment of toxicological behaviour of butylethanolamine is based on its physico-chemical properties and on the results of available toxicity data data.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-butylaminoethanol
EC Number:
203-904-5
EC Name:
2-butylaminoethanol
Cas Number:
111-75-1
Molecular formula:
C6H15NO
IUPAC Name:
2-(butylamino)ethan-1-ol
Constituent 2
Reference substance name:
Butylethanolamine
IUPAC Name:
Butylethanolamine
Test material form:
other: liquid
Details on test material:
- Name of test material (as cited in study report): Butylethanolamine
Radiolabelling:
no

Results and discussion

Main ADME resultsopen allclose all
Type:
absorption
Results:
BEA is expected to be absorbed from GI tract by passive diffusion. A high systemic availability via dermal and inhalation routes is unlikely.
Type:
distribution
Results:
BEA is expected to be predominantly distributed into the intravascular compartment due to its MW of 117.2 g/mol and high water solubility. BEA can also enter the cell inner (LogPow of 0.64). No risk for accumulation is expected for BEA (LogPow is <3.0).
Type:
metabolism
Results:
Hydroxylation and oxidation reactions by Phase I enzymes; conjugation reactions.
Type:
excretion
Results:
BEA is expected to be excreted primarily via the urine due to its MW (117.2 g/mol), vapour pressure (13.94 Pa) and high water solubility (1000 g/L).

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
Derivatives of hydroxilation and oxidation reactions.

Applicant's summary and conclusion

Conclusions:
Interpretation of results: no bioaccumulation potential based on study results
No bioaccumulation potential for BEA.
Executive summary:

An assessment of the toxicokinetic behaviour of butylethanolamine was performed, taking into account the chemical structure, the available physico-chemical-data and the available toxicity data. BEA is expected to be absorbed from GI tract by passive diffusion. A high systemic availability via dermal and inhalation routes is unlikely. BEA is expected to be predominantly distributed into the intravascular compartment due to its MW of 117.2 g/mol and high water solubility (1000 g/L). BEA can also enter the cell inner (LogPow of 0.62). No risk for accumulation is expected for BEA (LogPow is < 3.0). Possible reactions: hydroxylation and oxidation by Phase I enzymes with subsequent conjugation reactions. BEA is expected to be excreted primarily via the urine due to it MW (117.2 g/mol), vapour pressure (13.94 Pa) and the high water solubility (1000 g/L).