Registration Dossier
Registration Dossier
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EC number: 223-989-2 | CAS number: 4156-21-2
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Absorption: The test material is expected to be readily bio-available at the portal of entry and also in systemic circulation.
Distribution: Ready systemic distribution beyond the portal of entry is expected. The substance is not expected to accumulate in fatty tissues.
Metabolism: Significant metabolism is expected due to the intended reactivity of the chlorinated triazine moiety with nucleophils like water or proteins. The main expected reaction is an inactivation by hydrolysis.
Excretion: The test material as well as the expected hydrolysis products are soluble in water, ready excretion in mammals is expected via the kidney.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
The test material has the chemical structure of sodium p-[(4,6-dichloro-1,3,5-triazin-2-yl)-amino]-benzene-sulphonate. The pH-Value of aqueous solutions is almost neutral. Due to the presence of a sulfonic acid salt moiety the substance is polar and well soluble in water. The partition coefficient was determined as -0.48, which means that the substance is about 10 times as soluble in water compared to octanol. The substance is used in leather tanning as a tanning agent und textile fiber treatment. The mechanism of this action most probably is based on the ability to bind covalently to fibers and crosslink proteins.
The material is corrosive in vivo to mucous membranes.
Absorption: The test material is soluble in water and octanol. Via its local corrosive effects the substance can destroy the natural barriers of mucous membranes. Therefore it is expected to be readily bio-available at the portal of entry and also in systemic circulation. This notion is supported by the observed systemic toxicity in several test systems.
Distribution: Due to the good solubility of the substance, ready systemic distribution beyond the portal of entry is expected. The substance is not expected to accumulate in fatty tissues.
Metabolism: The test material has a molecular weight about 414 Dalton and is easily soluble at physiologic pH. Significant metabolism is expected due to the intended reactivity of the chlorinated triazine moiety with nucleophils like water or proteins. The main expected reaction is an inactivation by hydrolysis.
Excretion: The test material as well as the expected hydrolysis products are soluble in water, ready excretion in mammals is expected via the kidney.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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