Citronellyl acetate

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: acceptable data, no GLP, TS purity not specified;

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1971

Report date:

1971

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

acute dermal toxicity study

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Citronellyl acetate

EC Number:

205-775-0

EC Name:

Citronellyl acetate

Cas Number:

150-84-5

Molecular formula:

C12H22O2

IUPAC Name:

3,7-dimethyloct-6-en-1-yl acetate

Test material form:

not specified

Details on test material:

- Lot/batch No.: RIFM-70-462
No further details provided

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 2.5 – 3.1 kg
- Observation period before study: 7 d
- Housing: individually in hanging rabbit cages
- Food and water: ad libitum

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

TEST SITE
- Area of exposure: 24 h before the dermal applications: an area on the backs of the animals was shaved (ca. 30% of total body surface), animals were returned to the cages to allow the stratum corneum to recover
- Type of wrap: impervious plastic secured with tape

TEST MATERIAL
- Concentration (if solution): undiluted test material
- Constant volume or concentration used: yes

Duration of exposure:

24 h

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

2

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: mortality, initial and final body weight, behavioral abnormalities, skin reactions

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Mortality:

0/4 deaths

Clinical signs:

no effects; no behavioral abnormalities

Body weight:

No evident effect observed

Gross pathology:

no gross findings at necropsy

Other findings:

Local skin reactions:
after 24 h: irritant effects - definite red erythema, mild edema
after 6 d: superficial escharosis
end of the 14-day observation period: sloughing