Oligomerisation products of sucrose with ethylene oxide and methyloxirane

Endpoint summary

Additional information

Sucrose, ethoxylated and propoxylated (>1 -<16.5 moles EO and >1 -<16.5 moles PO) is a relatively non-volatile liquid at room temperature (Vapour pressure 0.000019 hPa at 20^oC) . The commercial material is soluble in water (634.6 g/l - 979.7 g/l at 19.8° C) and has a log P of 0.734 at 25° C. It is essentially non-toxic.

 

There are no studies on the toxicokinetics of sucrose, ethoxylated and propoxylated (>1 -<16.5 moles EO and >1 -<16.5 moles PO). The approach employed in this toxicokinetics assessment is to examine data for the repeating unit and initiating agent, sucrose, and NLPs made using sucrose as initiating agent and 1-methyl-2-oxirane as the chain-lengthening agent (in ascending order of multiples of the repeating unit). The data therefore comes from studies on sucrose, propane-1,2-diol, and oligomers of propane-1,2-diol. Some additional information is available from the fatty esters of sucrose used as substitutes for dietary fat. Conclusions for the longer oligomers are based on those data and on structure activity information." (cited from Illing, H P A, Barratt, M D (2007 revised 2009). Grouping of NLP ‘Polyols’ and their Toxicokinetics Assessments. Confidential report to the European Diisocyanate and Polyols Producers Association. December 2007, revised 2009.) Sucrose, ethoxylated and propoxylated (>1 -<16.5 moles EO and >1 -<16.5 moles PO) can be reliably included into this read accross.

Discussion on bioaccumulation potential result:

There are no experimental studies on the toxicokinetics of ethoxylated and propoxylated sucrose. Sucrose (the core substance) and propane-1,2-diol and oligomers (the propoxylated side chains) are possible models for the absorption of the ethoxylated and propoxylated sucrose. Sucrose has eight free hydroxy groups, thus oligomers are likely to consist of chains of between one and three monomers.

 

Sucrose is unlikely to be absorbed by passive diffusion, but, if absorbed by passive diffusion, absorption would be in the stomach and upper intestine where the alcohol groups are unionised. Sucrose is hydrolysed in the brush border of the intestine and the two monosaccharides, fructose and glucose, and these carbohydrates are absorbed by active transport. Propane-1,2-diol and [(methylethylene)bis(oxy)]dipropanoloxydipropanol are absorbed when administered orally, probably by passive diffusion. Essentially, the propoxylated sucrose is non-toxic. (partly cited from Illing, H P A, Barratt, M D (2007 revised 2009). Grouping of NLP ‘Polyols’ and their Toxicokinetics Assessments. Confidential report to the European Diisocyanate and Polyols Producers Association. December 2007, revised 2009.)