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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From February 11 to 15, 2000
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
The study was conducted according to an internationally recognised method, and under GLP. The substance is considered to be adequately characterised with its purity. Therefore full validation applies.
Reason / purpose:
reference to other study
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Version / remarks:
30th March 1989
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Version / remarks:
Directive 92/69/EEC
Deviations:
no
Principles of method if other than guideline:
Not applicable
GLP compliance:
yes (incl. certificate)
Remarks:
inspected on September 22, 1999 / signed on January 18, 2000
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
2.94
Temp.:
21 °C
pH:
ca. 0 - ca. 14

 Substance  retention time (tr)  k'  log Pow
 Formamide (dead time)  1.54 min  ---  ---
 Methyl benzoate  3.13 min  1.04  2.1
 Toluene  4.77 min  2.11  2.7
 Bromobenzene  5.30 min  2.45  3.0
 Naphthalene  6.74 min  3.39  3.6
 Benzyl benzoate  8.40 min  4.47  4.0
 Phenanthrene  16.5 min  9.76  4.5
 ST 16 C 99  4.90 min  2.19  2.94 ± 0.01

Log Pow = 2.64 * log k' + 2.04

r2 = 0.96

Conclusions:
The substance has low potential to bioaccumulate in the environment, according to CLP classification criteria for aquatic chronic toxicity (log Kow <4).
Executive summary:

The partition coefficient of the test substance was measured under GLP according to the OECD 117/EU A8 guideline, HPLC method.

The system was adequately calibrated with 6 reference substances, and the test substance was interpolated from the regression.

Partition coefficient (log Kow) = 2.94 at 21°C.

Description of key information

The substance has low potential to bioaccumulate in the environment, according to CLP classification criteria for aquatic chronic toxicity (log Kow <4).

Key value for chemical safety assessment

Log Kow (Log Pow):
2.94
at the temperature of:
21 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EC method and under GLP, is available. Therefore, it is considered as a key study, and the result is retained as key value.