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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Adopted according to EU risk assessment report, Cas No. 26447-40-5, methylenediphenyl diisocyanate (MDI), volume 59 (public available peer reviewed source)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1994
Report Date:
1994

Materials and methods

Study type:
clinical case study
Endpoint addressed:
skin irritation / corrosion
Test guideline
Qualifier:
no guideline required
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 4,4'-MDI (Rock glue)
- Analytical purity: not reported

Method

Type of population:
occupational
Subjects:
- Number of subjects exposed: no data
Route of exposure:
dermal
Reason of exposure:
unintentional, occupational
Exposure assessment:
not specified

Results and discussion

Clinical signs:
Some of the exposed miners described skin contact leading to chronic skin irritation. One current worker described continuing dermatitis of several years duration with continued rock glue exposure.
Results of examinations:
The skin contact resulted skin irritation.

Applicant's summary and conclusion

Conclusions:
The skin contact resulted skin irritation.