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Ecotoxicological information

Toxicity to birds

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
long-term toxicity to birds
Data waiving:
other justification
Justification for data waiving:
other:

Description of key information

No data is available on the toxicity to birds for the test substance. Based on the available mammalian toxicity data and the hydrolytic instability of MDI, it is not deemed necessary to perform toxicity tests to birds.

Key value for chemical safety assessment

Additional information

Toxicity data in rats (REACH section 7.2) and dogs (REACH section 7.11) show no overt toxicity by the oral route. Oral PMDI to rats showed the LD50 to be in excess of 10,000 mg/kg body weight. Ingested MDI forms mainly solid, inert polyureas. There is no reason to suppose that MDI will show significant oral toxicity to birds. Additionally, due to the hydrolytic instability of MDI, MDI will not be available in the environment to bioaccumulate into birds. Therefore no tests are deemed necessary.