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Physical & Chemical properties

Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
21 April 2017 - 06 November 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
Study was conducted in accordance with international guidelines and in accordance with GLP. All guideline validity criteria were met.
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
Regulation (EC) 440/2008 of 30 May 2008
Deviations:
no
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
11 July 2006
Deviations:
no
Qualifier:
equivalent or similar to
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Version / remarks:
August 1996
Deviations:
not specified
GLP compliance:
yes (incl. certificate)
Type of method:
dynamic method
Remarks:
Vapour–liquid equilibrium (VLE)
Key result
Test no.:
#1
Temp.:
20 °C
Vapour pressure:
0.09 hPa
Key result
Test no.:
#2
Temp.:
25 °C
Vapour pressure:
0.13 hPa
Key result
Test no.:
#3
Temp.:
50 °C
Vapour pressure:
0.52 hPa

Table 2:       Measured Vapour Pressures

No.

Temperature / °C

Vapour pressure / hPa

1

132.5

16.0

2

146.0

24.9

3

161.6

34.8

4

168.7

44.9

5

175.0

54.8

6

176.8

64.9

Note: The three control data points (deacresing vapour pressure values) were not evaluated due to test item decomposition.

The vapour pressure of the test item was calculated to be:

Table 3:       Calculated Vapour Pressures

Temperature (℃) Vapour Pressure (hPa)
 20  0.09
 25  0.13
 50  0.52
Conclusions:
The vapour pressure of the test item was calculated using the dynamic method in accordance with test guideline EU A.4 and OECD guideline 104 (2006).

The vapour pressure was calculated by extrapolation of measured vapour pressure data for 20 ̊C (VP = 0.09 hPa), 25 ̊C (VP = 0.13 hPa) and 50 ̊C (VP = 0.52 hPa).
Executive summary:

EU Method A.4. – The vapour pressure of the test item was determined utilising the Dynamic method (vapour–liquid equilibrium).  The procedure employed was designed to be compatible with Method A.4. Vapour Pressure of Commission Regulation (EC) No 440/2008 of 30 May 2008.

The vapour pressure of the test item was measured across a temperature range of 132.5 to 176.8 °C.  Values measured across this range showed a good linear response.  The test item vapour pressure at 20 °C, 25 °C and 50 °C was extrapolated from a regression of measured values.  

The vapour pressure of the test item has been determined to be 0.09 hPa at 20.0 °C.

Description of key information

Vapour Pressure: 0.09 hPa at 20°C; EU Method A.4.; H Smeykal (2017)

Key value for chemical safety assessment

Vapour pressure:
0.09 hPa
at the temperature of:
20 °C

Additional information

EU Method A.4. – The vapour pressure of the test item was determined utilising the Dynamic method (vapour–liquid equilibrium).  The procedure employed was designed to be compatible with Method A.4. Vapour Pressure of Commission Regulation (EC) No 440/2008 of 30 May 2008.

The vapour pressure of the test item was measured across a temperature range of 132.5 to 176.8 °C.  Values measured across this range showed a good linear response.  The test item vapour pressure at 20 °C, 25 °C and 50 °C was extrapolated from a regression of measured values.  

The vapour pressure of the test item has been determined to be 0.09 hPa at 20.0 °C.