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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2018
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Reference:
Composition 0
Qualifier:
equivalent or similar to
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
Deviations:
yes
Remarks:
one sample per concentration only; octanol:water no variation in volumes tested. Analytics is not substance specific (only titration of acid). Report does not conform with guideline.
GLP compliance:
no
Type of method:
flask method
Partition coefficient type:
octanol-water
Test material information:
Composition 1
Analytical method:
titration method
Type:
Pow
Partition coefficient:
3
Temp.:
23 °C
pH:
> 0 - < 0.5
Remarks on result:
other: starting concentration between 0.5 and 1 mol/L
Key result
Type:
Pow
Partition coefficient:
0.46
Temp.:
23 °C
pH:
1.7
Remarks on result:
other: concentration of aqueous phase before shaking = 0.01 mol/L

Konzentration

Verteilungskoeffizent

Stammlösung

organische Phase

wässrige Phase

 

mol/l

mol/l

mol/l

Kow

0,987

0,676

0,2245

3,01

0,50

0,330

0,110

3,00

0,749

0,480

0,160

3,00

 

 

Æ

3,0

Conclusions:
The log Kow of PFBS was dermined with shake flask method to be -0.34 at 23°C and pH of 1.7

Description of key information

The logKow of PFBS was determined as -0.34 in a 0.01 mol/L concentration (pH 1.7) at 23°C.

Key value for chemical safety assessment

Log Kow (Log Pow):
-0.34
at the temperature of:
23 °C

Additional information