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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1973
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report Date:
1973

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No guideline or method detailed in report.
GLP compliance:
no
Remarks:
Pre-GLP study.
Test type:
fixed dose procedure
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Specific details on test material used for the study:
Test material was described with the generic name "alpha-methylcinnamaldehyde". As manufactured by Innospec, the product met the criteria of > 80% trans-isomer, supporting that the test material was the isomer better described as CAS 15174-47-7.

Compound No.: RIFM 72-257
Clear liquid

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
Not specified
Duration of exposure:
Not specified
Doses:
5 gm/Kg bw
No. of animals per sex per dose:
10 animals
Control animals:
not specified

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Mortality:
No mortality was observed at 5000 mg/Kg bw

Any other information on results incl. tables

Table 1. Distribution of Mortality

Dose

(g/Kg)

Observation Day

Mortality

1

2

3

4

5

6

7

8

9

10

11

12

13

14

5.0

0

0

0

0

0

0

0

0

0

0

0

0

0

0

0/10

Applicant's summary and conclusion

Interpretation of results:
other: Not classified
Remarks:
Regulation (EC) No 1272/2008 on classification, labelling and packaging (CLP) of substances and mixtures
Conclusions:
The acute dermal LD50 of Alpha methyl cinnamic aldehyde was determined to be >5000 mg/Kg.
Executive summary:

In a key acute dermal toxicity study, the test material (Alpha methyl cinnamic aldehyde) was dermally administered to rabbits (10/dose) at a dose of 5000 mg/Kg (5 g/Kg).

 

No mortality was observed through the study period.

 

The acute dermal LD50 of Alpha methyl cinnamic aldehyde was therefore determined to be >5000 mg/Kg.